TBX21

Name	T-box transcription factor 21
Structure	No pdb structure
Interactors	3 interactors: EXOC5 HOXC11 ZNF490
GO Annotations	Cellular Component	Chromatin Nucleus Neuronal Cell Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification T-helper 1 Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Virus Positive Regulation Of Gene Expression T Cell Differentiation Negative Regulation Of Interleukin-2 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Lymphocyte Migration Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways	Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
GWAS	Ankylosing spondylitis ( 23749187 ) Asthma ( 34103634 31619474 30929738 ) Asthma (childhood onset) ( 31036433 ) Autoimmune thyroid disease ( 32581359 ) Body mass index ( 28448500 26426971 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Brain morphology (MOSTest) ( 32665545 ) Diverticular disease ( 30177863 ) Hip circumference adjusted for BMI ( 34021172 ) Mean corpuscular hemoglobin ( 27863252 ) Mean corpuscular volume ( 27863252 ) Multiple sclerosis ( 22190364 ) Simvastatin-induced myopathy ( 31220337 )
Entrez ID	30009
HPRD ID	05355
Ensembl ID	ENSG00000073861
Uniprot IDs	Q9UL17
PDB IDs	Not available