EML4

Name	EMAP like 4
Structure
Novel Interactors	1 novel interactors: MTCH1
Interactors	6 interactors: ARIH2 ARL4D NEK6 NEK7 TUBA1B TUBB
GO Annotations	Cellular Component	Cytoplasm Microtubule Organizing Center Spindle Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Membrane Midbody Intercellular Bridge Mitotic Spindle
	Molecular Function	Protein Binding Microtubule Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Mitotic Metaphase Chromosome Alignment Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways	EML4 and NUDC in mitotic spindle formation ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Diseases	Non-small cell lung cancer
GWAS	Chronic obstructive pulmonary disease ( 30804561 ) Hip circumference adjusted for BMI ( 34021172 ) Lung function (FEV1) ( 30061609 ) Metabolite levels ( 23823483 ) PR interval ( 32439900 ) Type 2 diabetes ( 31118516 )
Entrez ID	27436
HPRD ID	06310
Ensembl ID	ENSG00000143924
Uniprot IDs	B5MBZ0 Q9HC35
PDB IDs	4CGC
GO Terms Enriched among Interactors ?	Microtubule Spindle Assembly Microtubule Cytoskeleton Organization Spindle Organization Nucleotide Binding Ubiquitin Protein Ligase Binding Microtubule-based Process Membraneless Organelle Assembly GTPase Activity GTP Binding Cytoskeleton Organization Cell Division Structural Constituent Of Cytoskeleton Protein Localization To Extracellular Region Protein Secretion Establishment Of Protein Localization To Extracellular Region Organelle Organization Mitotic Cell Cycle Cytoskeleton Cellular Localization Establishment Of Localization In Cell Spindle Pole Structural Molecule Activity Organelle Assembly Cytoskeleton-dependent Intracellular Transport Odontoblast Differentiation Microtubule Cytoskeleton Mitotic Nuclear Membrane Disassembly Regulation Of Chromosome Organization Neuronal Ion Channel Clustering Positive Regulation Of Interleukin-18 Production GTPase Activating Protein Binding Nuclear Envelope Lumen Protein Insertion Into Mitochondrial Outer Membrane Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Cellular Response To Potassium Ion Cul5-RING Ubiquitin Ligase Complex Nuclear Membrane Disassembly Membrane Disassembly Membrane Insertase Activity MHC Class I Protein Binding