SIGLEC7

Name	sialic acid binding Ig like lectin 7
Structure
Interactors	5 interactors: GRB2 LGALS3BP PTPN11 SMIM1 TRAF4
GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process	Cell Adhesion
Pathways	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs	N-acetyl-alpha-D-glucosamine
GWAS	High light scatter reticulocyte percentage of red cells ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Entrez ID	27036
HPRD ID	05102
Ensembl ID	ENSG00000168995
Uniprot IDs	Q9Y286
PDB IDs	1NKO 1O7S 1O7V 2DF3 2G5R 2HRL
GO Terms Enriched among Interactors ?	Phosphotyrosine Residue Binding T Cell Costimulation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase Binding ERBB Signaling Pathway Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of MAPK Cascade Grb2-EGFR Complex Intestinal Epithelial Cell Migration Signal Transduction In Response To DNA Damage Cerebellar Cortex Formation Negative Regulation Of Glucocorticoid Secretion Neurotrophin TRKA Receptor Binding Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Platelet Dense Granule Lumen Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Atrioventricular Canal Development Microvillus Organization Regulation Of Neutrophil Activation Regulation Of Growth Hormone Secretion Peptide Hormone Receptor Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Bergmann Glial Cell Differentiation Neutrophil Activation Involved In Immune Response Thioesterase Binding Respiratory Tube Development