SIPA1L1

Name	signal induced proliferation associated 1 like 1
Structure	No pdb structure
Interactors	5 interactors: CEBPE DLG4 DSCAM NRXN1 UBE3A
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Postsynaptic Density Actin Cytoskeleton Neuron Projection Dendritic Spine Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Actin Cytoskeleton Organization Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Dendritic Spine Morphogenesis Activation Of GTPase Activity
Pathways	Neurexins and neuroligins
GWAS	Age at first birth ( 34211149 ) Bone mineral density (hip) ( 30172743 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) General factor of neuroticism ( 30867560 ) Heart rate variability traits (RMSSD) ( 28613276 ) Heart rate variability traits (SDNN) ( 28613276 ) Mitral valve prolapse ( 26301497 ) Neuroticism ( 29255261 ) Obesity-related traits ( 23251661 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) PR interval ( 30046033 ) QRS duration ( 30012220 30679814 27659466 27577874 ) Sociability score ( 34054130 ) Strenuous sports or other exercises ( 29899525 )
Entrez ID	26037
HPRD ID	11559
Ensembl ID	ENSG00000197555
Uniprot IDs	O43166
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Social Behavior Neuroligin Family Protein Binding NMDA Selective Glutamate Receptor Signaling Pathway Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Vocalization Behavior Positive Regulation Of Excitatory Postsynaptic Potential Cell Projection Morphogenesis Ionotropic Glutamate Receptor Signaling Pathway Neuron Projection Morphogenesis Receptor Clustering Glutamate Receptor Signaling Pathway Neuromuscular Process Controlling Balance Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Protein Localization To Synapse Cell-cell Adhesion P2Y1 Nucleotide Receptor Binding Neuron Projection Development Protein Localization To Cell Junction Neuromuscular Junction Modulation Of Chemical Synaptic Transmission Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Glutamatergic Synapse Synapse Assembly Cell-cell Signaling Neuromuscular Process Regulation Of Nervous System Process Signaling Cell Communication Regulation Of Cell Projection Organization Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Synaptic Vesicle Positive Regulation Of Synaptic Transmission Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Learning Regulation Of Golgi Lumen Acidification