TRIM58

Name	tripartite motif containing 58
Structure
Interactors	3 interactors: DYNC1I1 MECOM UBE2D3
GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Zinc Ion Binding Transferase Activity Dynein Heavy Chain Binding Dynein Intermediate Chain Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response Protein Autoubiquitination Positive Regulation Of Erythrocyte Enucleation Regulation Of Nuclear Migration Along Microtubule
GWAS	Blood metabolite levels ( 26401656 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 27863252 ) High light scatter reticulocyte percentage of red cells ( 32888494 27863252 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 27863252 32888494 29403010 ) Mean corpuscular volume ( 27863252 32888494 28017375 28453575 20139978 29403010 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil count ( 32888494 ) Platelet count ( 32888494 29403010 27863252 22139419 ) Platelet distribution width ( 32888494 27863252 ) Red blood cell count ( 32888494 27863252 ) Red blood cell fatty acid levels ( 25500335 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 28957414 32888494 27863252 ) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Serum metabolite levels ( 33031748 ) Systemic juvenile idiopathic arthritis ( 27927641 ) White blood cell count ( 27863252 32888494 )
Entrez ID	25893
HPRD ID	09825
Ensembl ID	ENSG00000162722
Uniprot IDs	Q8NG06
PDB IDs	8PD4 8PD6
GO Terms Enriched among Interactors ?	Dynein Light Chain Binding Histone H3K9me2 Methyltransferase Activity Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone H3K9 Monomethyltransferase Activity Histone H3K9 Methyltransferase Activity