FGF9

Name	fibroblast growth factor 9
Structure
Interactors	4 interactors: FGFR1 FGFR2 FGFR3 FGFR4
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Osteoblast Differentiation Eye Development Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Protein Import Into Nucleus Signal Transduction Smoothened Signaling Pathway Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Mesenchymal Cell Proliferation Positive Regulation Of Gene Expression Wnt Signaling Pathway Substantia Nigra Development Neurogenesis Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Male Sex Determination Lung Development Embryonic Limb Morphogenesis Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Inner Ear Morphogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Smoothened Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Timing Of Cell Differentiation Embryonic Digestive Tract Development Embryonic Skeletal System Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Sertoli Cell Proliferation Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Lung-associated Mesenchyme Development Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Positive Regulation Of Stem Cell Proliferation
Pathways	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional regulation of testis differentiation
GWAS	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Aspartate aminotransferase levels ( 33547301 ) Asthma (childhood onset) ( 27611488 ) Central corneal thickness ( 29760442 ) Chin dimples ( 27182965 ) Corneal structure ( 23291589 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945 ) Systolic blood pressure ( 30224653 ) Type 2 diabetes ( 32499647 )
Entrez ID	2254
HPRD ID	02951
Ensembl ID	ENSG00000102678
Uniprot IDs	P31371
PDB IDs	1G82 1IHK 5W59
GO Terms Enriched among Interactors ?	Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Lipase Activity Protein Tyrosine Kinase Activity Receptor Complex Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Positive Regulation Of Catalytic Activity Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Forebrain Neuroblast Division Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Biomineral Tissue Development Forebrain Ventricular Zone Progenitor Cell Division Protein Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Lung-associated Mesenchyme Development Protein Autophosphorylation Endochondral Bone Growth Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Branching Involved In Salivary Gland Morphogenesis Heparin Binding Positive Regulation Of ERK1 And ERK2 Cascade Bone Growth Positive Regulation Of Cell Population Proliferation Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intracellular Signal Transduction Midbrain Development Regulation Of Developmental Growth Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Positive Regulation Of Heart Growth Protein Phosphorylation Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation ATP Binding Phosphorylation