FGF6

Name	fibroblast growth factor 6
Structure	No pdb structure
Novel Interactors	2 novel interactors: CELSR1 KLRC2
Interactors	5 interactors: FGFR1 FGFR2 FGFR3 FGFR4 NCALD
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Sarcolemma
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Cartilage Condensation Angiogenesis Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Neurogenesis Cell Differentiation Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Myoblast Differentiation Positive Regulation Of Cell Division
Pathways	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 FGFR4 ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
GWAS	Colorectal cancer ( 23263487 ) Medication use (antimigraine preparations) ( 31015401 ) Migraine ( 27182965 27322543 ) Migraine without aura ( 27322543 ) Phosphorus levels ( 20558539 29403010 ) Response to cytadine analogues (cytosine arabinoside) ( 24483146 )
Entrez ID	2251
HPRD ID	00623
Ensembl ID	ENSG00000111241
Uniprot IDs	A0A7U3JW05 P10767
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Fibroblast Growth Factor Receptor Activity Fibroblast Growth Factor Binding Positive Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Fibroblast Growth Factor Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Ventricular Zone Neuroblast Division Orbitofrontal Cortex Development Peptidyl-tyrosine Phosphorylation Forebrain Neuroblast Division Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Catalytic Activity Lung-associated Mesenchyme Development Endochondral Bone Growth Lateral Sprouting From An Epithelium Biomineral Tissue Development Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Bone Growth Protein Kinase Activity Heparin Binding Regulation Of Catalytic Activity Positive Regulation Of ERK1 And ERK2 Cascade Mesenchymal Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Kinase Activity Signal Transduction Gland Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Midbrain Development Regulation Of Mesenchymal Cell Proliferation Bone Morphogenesis Positive Regulation Of Heart Growth Response To Fibroblast Growth Factor Ureteric Bud Development Regulation Of Cardiac Muscle Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Organ Growth