DEFA6

Name	defensin alpha 6
Structure
Interactors	5 interactors: APP SGTA SGTB UBQLN1 UBQLN2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Transport Vesicle Cytoplasmic Vesicle
	Molecular Function	Protein Binding Protein Homodimerization Activity Pore-forming Activity
	Biological Process	Immune System Process Defense Response Antibacterial Humoral Response Killing Of Cells Of Another Organism Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Disruption Of Plasma Membrane Integrity In Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways	Defensins Alpha-defensins
GWAS	Blood pressure ( 24954895 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Night sleep phenotypes ( 27126917 )
Entrez ID	1671
HPRD ID	02719
Ensembl ID	ENSG00000164822
Uniprot IDs	Q01524
PDB IDs	1ZMQ 3QTE
GO Terms Enriched among Interactors ?	Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway TRC Complex Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Identical Protein Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Response To Endoplasmic Reticulum Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Polyubiquitin Modification-dependent Protein Binding Protein Targeting To Membrane Regulation Of Receptor Internalization Proteasomal Protein Catabolic Process Autophagosome Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Assembly Protein-folding Chaperone Binding Autophagosome Organization Protein Catabolic Process Regulation Of Receptor-mediated Endocytosis Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Proteolysis Involved In Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization PTB Domain Binding Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production