GSC

Name	goosecoid homeobox
Structure
Novel Interactors	1 novel interactors: FBLN5
Interactors	4 interactors: FOXA2 SMAD1 SMAD2 SMAD3
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Anatomical Structure Morphogenesis Tissue Development Neural Crest Cell Fate Specification Wnt Signaling Pathway Dorsal/ventral Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Forebrain Development Middle Ear Morphogenesis Ear Development Animal Organ Development Muscle Organ Morphogenesis Embryonic Skeletal System Morphogenesis
Pathways	Germ layer formation at gastrulation Formation of definitive endoderm
GWAS	Chin dimples ( 27182965 ) Male-pattern baldness ( 28196072 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Nose size ( 27182965 )
Entrez ID	145258
HPRD ID	15928
Ensembl ID	ENSG00000133937
Uniprot IDs	P56915
PDB IDs	2DMU
GO Terms Enriched among Interactors ?	Heteromeric SMAD Protein Complex SMAD Protein Complex Primary MiRNA Processing Co-SMAD Binding I-SMAD Binding SMAD Protein Signal Transduction MiRNA Processing Homomeric SMAD Protein Complex Ureteric Bud Development Mesonephric Epithelium Development Mesonephric Tubule Development Paraxial Mesoderm Morphogenesis Embryonic Pattern Specification Negative Regulation Of Developmental Process Kidney Epithelium Development Mesoderm Morphogenesis Pericardium Development Trophoblast Cell Migration DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway DEAD/H-box RNA Helicase Binding Regulation Of Epithelial To Mesenchymal Transition Embryonic Foregut Morphogenesis Nodal Signaling Pathway Transforming Growth Factor Beta Receptor Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cell Differentiation Positive Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Tube Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding Epithelium Development Transcription Regulator Complex Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Regulation Of Osteoblast Proliferation Positive Regulation Of Cartilage Development Endoderm Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ubiquitin Protein Ligase Binding Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Negative Regulation Of Ossification