GAB3

Name	GRB2 associated binding protein 3
Structure	No pdb structure
Interactors	8 interactors: CSF1 FYN GRAP2 GRB2 LYN PIK3R1 PTPN11 SRC
GO Annotations	Cellular Component	Cytoplasm
	Molecular Function	Signaling Adaptor Activity
	Biological Process	Signal Transduction Macrophage Differentiation
Pathways	Signaling by CSF1 (M-CSF) in myeloid cells
GWAS	Glycated hemoglobin levels ( 34059833 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 28453575 ) Mean spheric corpuscular volume ( 32888494 )
Entrez ID	139716
HPRD ID	06571
Ensembl ID	ENSG00000160219
Uniprot IDs	Q8WWW8
PDB IDs	Not available
GO Terms Enriched among Interactors ?	T Cell Costimulation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Activation Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Regulation Of Cell Adhesion Immune Effector Process Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Regulation Of Innate Immune Response Intracellular Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Immune System Process Leukocyte Migration Negative Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Regulation Of Defense Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Immune System Process Cell Motility Regulation Of Lymphocyte Activation Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Localization Negative Regulation Of Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling