MTPN

Name	myotrophin
Structure
Novel Interactors	1 novel interactors: ICAM1
Interactors	7 interactors: CAPZB CEBPA MAPK1 NFKB1 REL RELA RIPK4
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol F-actin Capping Protein Complex Perinuclear Region Of Cytoplasm
	Biological Process	Regulation Of Translation Regulation Of Cell Size Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Striated Muscle Tissue Development Neuron Differentiation Positive Regulation Of Cell Growth Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Metabolic Process Regulation Of Barbed-end Actin Filament Capping
GWAS	Alcoholic chronic pancreatitis ( 28754779 ) Mean platelet volume ( 32888494 ) Platelet count ( 27863252 ) Platelet distribution width ( 27863252 32888494 ) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683 )
Entrez ID	136319
HPRD ID	07574
Ensembl ID	ENSG00000105887
Uniprot IDs	P58546 Q69YG1
PDB IDs	3AAA 7DF7 7DSA 7DSB
GO Terms Enriched among Interactors ?	Response To Peptide Response To Cytokine Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor NF-kappaB P50/p65 Complex Non-canonical NF-kappaB Signal Transduction Cellular Response To Cytokine Stimulus Response To Nicotine NF-kappaB Complex Canonical NF-kappaB Signal Transduction Cellular Response To Nicotine Intracellular Signaling Cassette Actinin Binding Cytokine-mediated Signaling Pathway Regulation Of Inflammatory Response Cellular Response To Angiotensin Cellular Response To Interleukin-6 DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Immune System Process Sequence-specific DNA Binding Positive Regulation Of Defense Response Response To Interleukin-6 Positive Regulation Of Inflammatory Response Response To Angiotensin Inflammatory Response Response To Muscle Stretch Signal Transduction Involved In Regulation Of Gene Expression DNA-binding Transcription Factor Activity Transcription Regulator Complex Immune Response-activating Cell Surface Receptor Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To DsRNA Gland Development Immune Response-regulating Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding B Cell Receptor Signaling Pathway Response To Lipid Regulation Of Immune System Process Response To Lipopolysaccharide Regulation Of Defense Response Tumor Necrosis Factor-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Positive Regulation Of MiRNA Metabolic Process Regulation Of Interleukin-12 Production Negative Regulation Of Cytokine Production RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Immune Response-activating Signaling Pathway Positive Regulation Of DNA-templated Transcription Initiation Intracellular Signal Transduction