NCOA7

Name	nuclear receptor coactivator 7
Structure
Novel Interactors	1 novel interactors: TNFRSF25
Interactors	4 interactors: AHR ARNT ESR1 ESR2
GO Annotations	Cellular Component	Nucleus
	Molecular Function	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cellular Response To Oxidative Stress
GWAS	Brain morphology (MOSTest) ( 32665545 ) Brugada syndrome ( 35210625 23872634 ) Endometrial cancer ( 27135401 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Endometrial endometrioid carcinoma ( 27135401 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip index ( 34021172 ) Immature fraction of reticulocytes ( 32888494 ) Left–right brain asymmetry ( 33723403 ) Menarche (age at onset) ( 25231870 ) Migraine ( 27322543 ) Night sleep phenotypes ( 27126917 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum metabolite concentrations in chronic kidney disease ( 33838163 ) Subcortical volume (MOSTest) ( 32665545 ) Systolic blood pressure ( 30578418 30224653 ) Urate levels ( 31578528 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Entrez ID	135112
HPRD ID	14814
Ensembl ID	ENSG00000111912
Uniprot IDs	B3KXK4 H0Y5F6 Q8NI08
PDB IDs	7OBP 8AR6 8AR9
GO Terms Enriched among Interactors ?	Nuclear Receptor Activity Nuclear Aryl Hydrocarbon Receptor Complex Intracellular Receptor Signaling Pathway Nuclear Estrogen Receptor Activity Aryl Hydrocarbon Receptor Complex Intestinal Epithelial Structure Maintenance Estrogen Response Element Binding DNA-binding Transcription Factor Activity Maintenance Of Gastrointestinal Epithelium Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity TBP-class Protein Binding Transcription Regulator Complex Steroid Binding Epithelial Structure Maintenance Cellular Response To Estradiol Stimulus Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding Regulation Of Inflammatory Response Positive Regulation Of Transcription By RNA Polymerase II Digestive System Process Cellular Response To Lipid Sequence-specific DNA Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cis-regulatory Region Sequence-specific DNA Binding Cytosolic Aryl Hydrocarbon Receptor Complex Nuclear Receptor-mediated Signaling Pathway Sequence-specific Double-stranded DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Estradiol Positive Regulation Of DNA-binding Transcription Factor Activity Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Response To Lipid Signal Transduction Protein Dimerization Activity Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Defense Response DNA Binding Negative Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity