AGAP2

Name	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Structure
Novel Interactors	1 novel interactors: TBK1
Interactors	16 interactors: AKT1 ARF1 BTG3 CDC42 CDK4 EPB41L1 GRIP1 HOMER1 HOMER2 NF2 PIK3R1 PLCG1 PRKAA1 RAC1 RAC2 RHOA
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Membrane Extracellular Exosome Flemming Body
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Protein Kinase Binding Protein Kinase Activator Activity Phosphatidylinositol 3-kinase Regulator Activity Metal Ion Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Protein Transport Endosomal Transport Actin Cytoskeleton Organization Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Kinase Activity
Pathways	Netrin-1 signaling
GWAS	Heel bone mineral density ( 30598549 ) Multiple sclerosis ( 21833088 )
Entrez ID	116986
HPRD ID	05687
Ensembl ID	ENSG00000135439
Uniprot IDs	Q99490
PDB IDs	2BMJ 2IWR 2RLO
GO Terms Enriched among Interactors ?	Intracellular Signaling Cassette Intracellular Signal Transduction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Transport Regulation Of Stress Fiber Assembly Positive Regulation Of Lamellipodium Organization Regulation Of Actin Filament-based Process Regulation Of Cell-substrate Adhesion Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Cell Projection Organization Cytosol Membrane Invagination Regulation Of Actin Filament Organization Dendrite Regulation Of Lamellipodium Organization Positive Regulation Of Stress Fiber Assembly Cytoplasm Positive Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Vesicle-mediated Transport Regulation Of Organelle Organization Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Cell Motility Positive Regulation Of Cell Projection Organization Cell Projection Actin Cytoskeleton Organization Positive Regulation Of Locomotion Signal Transduction Regulation Of Supramolecular Fiber Organization Apical Part Of Cell Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Actin Filament-based Process Regulation Of Leukocyte Migration Positive Regulation Of Immune System Process Postsynapse Regulation Of Cell Projection Assembly Regulation Of Cell Motility Ruffle Membrane G Protein-coupled Glutamate Receptor Binding Regulation Of Cellular Component Organization Protein Kinase Binding Regulation Of Locomotion