NOSTRIN

Name	nitric oxide synthase trafficking
Structure
Novel Interactors	1 novel interactors: GLA
Interactors	6 interactors: APC KDM1A MAGEA6 NOS3 PRMT6 TULP3
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	DNA Binding Protein Binding
	Biological Process	Endocytosis Signal Transduction Negative Regulation Of DNA-templated Transcription
Pathways	NOSTRIN mediated eNOS trafficking
GWAS	Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Eosinophil count ( 32888494 ) Granulocyte count ( 27863252 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Mitochondrial DNA levels ( 25240745 ) Monocyte count ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 27863252 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 32888494 )
Entrez ID	115677
HPRD ID	06324
Ensembl ID	ENSG00000163072
Uniprot IDs	Q8IVI9
PDB IDs	2YUN
GO Terms Enriched among Interactors ?	Endocardial Cushion Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Smooth Muscle Hyperplasia Flavin Adenine Dinucleotide Binding Negative Regulation Of Muscle Hyperplasia Bronchus Morphogenesis Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Intraciliary Transport Particle A Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Signal Transduction Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Demethylase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Glycosylceramide Catabolic Process Cadmium Ion Binding MRF Binding Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Regulation Of Signal Transduction Positive Regulation Of Protein Localization To Centrosome Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Negative Regulation Of Oxidoreductase Activity Smooth Muscle Adaptation Regulation Of Systemic Arterial Blood Pressure By Endothelin L-arginine Catabolic Process Regulation Of The Force Of Heart Contraction By Chemical Signal Arginine Binding Embryonic Neurocranium Morphogenesis Response To Fungicide Histone H3K4 Demethylase Activity Guanine Metabolic Process Protein-arginine Omega-N Asymmetric Methyltransferase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Ovulation From Ovarian Follicle Tetrahydrobiopterin Metabolic Process