LACTB

Name	lactamase beta
Structure
Interactors	6 interactors: CALM1 OGT PAXIP1 PTPRF TP53 UBC
GO Annotations	Cellular Component	Mitochondrion Cytosol
	Molecular Function	Protein Binding Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Proteolysis Lipid Metabolic Process Regulation Of Lipid Metabolic Process
GWAS	Estimated glomerular filtration rate ( 31015462 31451708 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) HDL cholesterol ( 20686565 24097068 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Metabolic traits ( 21886157 ) Pulse pressure ( 27841878 ) Refractive error ( 32231278 ) Serum metabolite levels ( 23093944 33031748 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )
Entrez ID	114294
HPRD ID	07466
Ensembl ID	ENSG00000103642
Uniprot IDs	P83111
PDB IDs	7ULW 7V1Y 7V1Z 7V21
GO Terms Enriched among Interactors ?	Chondroitin Sulfate Proteoglycan Binding Regulation Of DNA-templated Transcription Initiation Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Helicase Activity Regulation Of Carbohydrate Catabolic Process Positive Regulation Of DNA-templated Transcription Initiation Autophagy Of Mitochondrion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of G1 To G0 Transition Positive Regulation Of Transcription Initiation By RNA Polymerase II Mitophagy DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Transcription Initiation By RNA Polymerase II Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle Regulation Of Cell Cycle Process Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Protein-containing Complex Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Intracellular Signal Transduction Negative Regulation Of Receptor Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nuclear Matrix Macroautophagy Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Proteolysis Glial Cell Apoptotic Process Response To Ionizing Radiation Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D