CHRNA3

Name cholinergic receptor nicotinic alpha 3 subunit
Structure PDB 4ZK4
Novel Interactors 4 novel interactors: CHRNA5 CRABP1 ETFA SCAMP2
Interactors 2 interactors: CHRNB4 UBQLN1
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
GWAS
  • Abdominal aortic aneurysm ( 32981348 )
  • Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 )
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 )
  • Autism spectrum disorder or schizophrenia ( 28540026 )
  • Benign childhood epilepsy with centro-temporal spikes ( 32580138 )
  • Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909 )
  • Chronic obstructive pulmonary disease ( 25101718 19300482 20173748 22080838 30804561 )
  • Chronic obstructive pulmonary disease (moderate to severe) ( 24621683 )
  • Chronic obstructive pulmonary disease (severe) ( 24621683 )
  • Chronic obstructive pulmonary disease x current smoker interaction (1df) ( 33106845 )
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 )
  • Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575 )
  • Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774 )
  • Dentures ( 31235808 )
  • Diffusing capacity of carbon monoxide ( 30694715 )
  • Emphysema distribution in smoking ( 27669027 )
  • Emphysema imaging phenotypes ( 26030696 )
  • Exhaled carbon monoxide levels ( 25072098 )
  • Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575 )
  • Familial lung cancer ( 29924316 )
  • Local histogram emphysema pattern ( 25006744 )
  • Lung adenocarcinoma ( 19836008 )
  • Lung cancer ( 30104567 18385738 18385676 18780872 19654303 )
  • Lung cancer in ever smokers ( 30104567 )
  • Lung function (FEV1/FVC) ( 31453325 )
  • Lung function (FEV1/FVC) variance ( 31453325 )
  • Nicotine dependence ( 18385739 26440539 )
  • Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808 )
  • Obesity-related traits ( 23251661 )
  • Parental lifespan ( 30642433 29030599 )
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965 )
  • Parental longevity (father's attained age) ( 29227965 )
  • Parental longevity (mother's attained age) ( 29227965 )
  • Peripheral artery disease ( 31285632 )
  • Post bronchodilator FEV1 ( 26634245 )
  • Post bronchodilator FEV1 in COPD ( 26634245 )
  • Post bronchodilator FEV1/FVC ratio ( 26634245 )
  • Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 )
  • Pre bronchodilator FEV1 ( 26634245 )
  • Pre bronchodilator FEV1/FVC ratio ( 26634245 )
  • Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718 )
  • Pulmonary function ( 21946350 )
  • Pulmonary function (smoking interaction) ( 23284291 )
  • Refractive error ( 32231278 )
  • Schizophrenia ( 30285260 25056061 29483656 28991256 )
  • Serum albumin levels ( 23022100 )
  • Smoking behavior ( 20418890 20418889 )
  • Smoking behaviour (cigarettes smoked per day) ( 30617275 31089300 )
  • Smoking status (heavy vs light) ( 28520984 )
  • Squamous cell lung carcinoma ( 28604730 )
Entrez ID 1136
HPRD ID 07511
Ensembl ID ENSG00000080644
Uniprot IDs P32297
PDB IDs 4ZK4 5SYO 5TVC 6PV7 6PV8
GO Terms Enriched among Interactors ?