CCT8

Name	chaperonin containing TCP1 subunit 8
Structure
Novel Interactors	2 novel interactors: IFNGR2 USP16
Interactors	5 interactors: ACTB APP CEBPA OGT PTEN
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Extracellular Region Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cilium Secretory Granule Lumen Azurophil Granule Lumen Cell Projection Cell Body Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
GWAS	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 )
Entrez ID	10694
HPRD ID	10816
Ensembl ID	ENSG00000156261
Uniprot IDs	P50990 Q7Z759
PDB IDs	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
GO Terms Enriched among Interactors ?	Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Proteolysis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Axonogenesis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Excitatory Postsynaptic Potential Developmental Maturation Microglial Cell Activation Reproductive Behavior Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Protein-containing Complex Neuron Projection Morphogenesis Regulation Of Cell Junction Assembly Neuron Projection Organization Learning Or Memory Cell Projection Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Organization Cognition Regulation Of Glycolytic Process Response To Stress Modulation Of Excitatory Postsynaptic Potential Synapse Negative Regulation Of Developmental Process Macrophage Activation Positive Regulation Of Metabolic Process Regulation Of Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding