MICA

Name	MHC class I polypeptide-related sequence A
Structure
Interactors	1 interactors: POT1
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Beta-2-microglobulin Binding Natural Killer Cell Lectin-like Receptor Binding Receptor Ligand Activity
	Biological Process	T Cell Mediated Cytotoxicity Adaptive Immune Response Immune System Process Immune Response To Tumor Cell Immune Response DNA Damage Response Signal Transduction Response To Heat Negative Regulation Of Defense Response Killing Of Cells Of Another Organism Negative Regulation Of Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Gamma-delta T Cell Activation Regulation Of Immune Response Defense Response To Virus
Pathways	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Diseases	Familial Mediterranean fever (FMF); Familial hereditary periodic fever syndromes
GWAS	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic sensitization ( 23817571 ) Asthma ( 27182965 29273806 31619474 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 31619474 29273806 ) Asthma and major depressive disorder ( 31619474 ) Atopic dermatitis ( 25574825 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Basophil percentage of white cells ( 27863252 ) Behcet's disease ( 23001997 ) Beta-2 microglubulin plasma levels ( 23417110 ) Blood protein levels ( 30072576 ) Cervical cancer ( 23482656 ) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208 ) Chronic obstructive pulmonary disease ( 30804561 ) Clozapine-induced agranulocytosis ( 25187353 ) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947 ) Cold sores ( 28928442 ) Cutaneous lupus erythematosus ( 25827949 ) Eosinophil count ( 29403010 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Gastroesophageal reflux disease ( 31527586 ) Heel bone mineral density ( 30598549 ) Height ( 20881960 ) Hepatocellular carcinoma ( 21499248 ) High density lipoprotein cholesterol levels ( 33339817 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) HIV-1 control ( 21051598 ) IgA levels ( 28628107 ) Inflammatory bowel disease ( 28067908 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Lung cancer in ever smokers ( 28604730 ) Malaria ( 31844061 ) Mononucleosis ( 28928442 ) Mosquito bite size ( 28199695 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Non-chemotherapy drug induced agranulocytosis ( 27157822 ) Offspring birth weight ( 31043758 ) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965 ) Parental longevity (father's attained age) ( 29227965 ) Perceived unattractiveness to mosquitoes ( 28199695 ) Platelet distribution width ( 27863252 ) Pneumonia ( 28928442 ) Psoriasis ( 23143594 ) Pubertal anthropometrics ( 23449627 ) Reticulocyte fraction of red cells ( 32888494 ) Rheumatoid arthritis (ACPA-negative) ( 24532677 ) Rosacea symptom severity ( 29771307 ) Self-reported allergy ( 23817569 ) Takayasu arteritis ( 25604533 23830517 33308445 ) Tonsillectomy ( 27182965 ) Trichloroethylene-induced hypersensitivity syndrome ( 26190474 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Weight ( 28552196 )
Entrez ID	100507436
HPRD ID	Not available
Ensembl ID	ENSG00000204520
Uniprot IDs	A0A024RCL3 A0A0G2JJ55 Q29983 Q96QC4
PDB IDs	1B3J 1HYR 6DDM 6DDR 6DDV 7FI5 7FI6 7FI7 7FI8 7FI9 8TLZ 8TM0 8TM2
GO Terms Enriched among Interactors ?	Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Telomerase Inhibitor Activity Shelterin Complex Establishment Of Protein Localization To Telomere Nuclear Telomere Cap Complex Telomeric D-loop Disassembly DEAD/H-box RNA Helicase Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Regulation Of DNA Strand Elongation Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding RNA-templated DNA Biosynthetic Process Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Organization Negative Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Chromosome, Telomeric Region Regulation Of DNA Repair Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Chromosome Organization Establishment Of Protein Localization To Organelle