TRAF7 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
HDGF	heparin binding growth factor	XBP1(S) activates chaperone genes	Copper
MAP3K3	mitogen-activated protein kinase kinase kinase 3	Interleukin-1 signaling	Fostamatinib
NUDT16L1	nudix hydrolase 16 like 1
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase	HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes
PBXIP1	PBX homeobox interacting protein 1
PPIC	peptidylprolyl isomerase C		Proline
RIPK4	receptor interacting serine/threonine kinase 4
TRAF6	TNF receptor associated factor 6	PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of NF-kappa B signaling MyD88 cascade initiated on plasma membrane
UBE2D1	ubiquitin conjugating enzyme E2 D1	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Inactivation of APC/C via direct inhibition of the APC/C complex TICAM1, RIP1-mediated IKK complex recruitment APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Signaling by BMP Downstream TCR signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Ovarian tumor domain proteases Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Aberrant regulation of mitotic exit in cancer due to RB1 defects Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UBE2D2	ubiquitin conjugating enzyme E2 D2	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	(R,R)-2,3-Butanediol
UBE2D4	ubiquitin conjugating enzyme E2 D4	Antigen processing: Ubiquitination & Proteasome degradation
UBE2K	ubiquitin conjugating enzyme E2 K	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
UBE2L3	ubiquitin conjugating enzyme E2 L3	PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling Regulation of necroptotic cell death Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
UBE2L6	ubiquitin conjugating enzyme E2 L6	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes

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