TRAF7 and PPIC

		TRAF7	PPIC
Description		TNF receptor associated factor 7	peptidylprolyl isomerase C
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Plasma Membrane Cytoplasmic Vesicle	Cytoplasm Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein K29-linked Ubiquitination Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Protein Folding
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Proline
Diseases
GWAS		Diastolic blood pressure ( 30578418) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Aortic root size ( 19584346) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		17 interacting genes: BTBD1 CYLD HAGHL HDGF MAP3K3 NUDT16L1 OGT PBXIP1 PPIC RIPK4 TRAF6 UBE2D1 UBE2D2 UBE2D4 UBE2K UBE2L3 UBE2L6	14 interacting genes: ARSA BANP CAPNS2 FAM25A FAM25C FAM25G LGALS3BP SGTA SGTB TRAF7 UBAP1 UBQLN1 UBQLN2 UBQLN4
Entrez ID		84231	5480
HPRD ID		06977	00459
Ensembl ID		ENSG00000131653	ENSG00000168938
Uniprot IDs		B3KQY7 Q6Q0C0	P45877
PDB IDs		8IMS	2ESL
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Protein Modification Process Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Transferase Activity Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Nucleotide Binding Ubiquitin-ubiquitin Ligase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Ubiquitination Ubiquitin-like Protein Transferase Activity ATP Binding Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Modification Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Regulation Of Necroptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Necrotic Cell Death Protein-containing Complex Regulation Of DNA-binding Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of P38MAPK Cascade Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Positive Regulation Of Protein Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Gene Expression Involved In Extracellular Matrix Organization Cytosol Positive Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction TORC1 Signaling Ripoptosome Assembly Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Autoubiquitination	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Cerebroside-sulfatase Activity Regulation Of Cellular Response To Stress Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Targeting To Membrane Identical Protein Binding Autophagy Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Proteolysis Establishment Of Protein Localization To Organelle Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Autophagosome Assembly BAT3 Complex Binding Autophagosome Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Autophagy Calpain Complex Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Vesicle Cytosolic Proteasome Complex Regulation Of Protein Metabolic Process Negative Regulation Of ERAD Pathway
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