Search Results for: POLE3

26 interactions involving POLE3 - DNA polymerase epsilon 3, accessory subunit found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
EIF4G2 eukaryotic translation initiation factor 4 gamma 2
  • ISG15 antiviral mechanism
GSN gelsolin
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Neutrophil degranulation
  • Sensory processing of sound by outer hair cells of the cochlea
  • Amyloid fiber formation
  • Zinc
  • Latrunculin A
  • Copper
  • Zinc acetate
  • Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome
  • Familial amyloidosis
POLE4 DNA polymerase epsilon 4, accessory subunit
  • Recognition of DNA damage by PCNA-containing replication complex
  • PCNA-Dependent Long Patch Base Excision Repair
  • Termination of translesion DNA synthesis
  • HDR through Homologous Recombination (HRR)
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • DNA replication initiation
  • Activation of the pre-replicative complex
  • Cladribine
SMARCA5 SNF2 related chromatin remodeling ATPase 5
  • NoRC negatively regulates rRNA expression
  • B-WICH complex positively regulates rRNA expression
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Deposition of new CENPA-containing nucleosomes at the centromere
  • Beta-D-Glucose
  • 4-Deoxy-Alpha-D-Glucose
TNC tenascin C
  • Integrin cell surface interactions
  • Syndecan interactions
  • ECM proteoglycans
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
TRIM32 tripartite motif containing 32
  • Regulation of innate immune responses to cytosolic DNA
  • Antigen processing: Ubiquitination & Proteasome degradation
  • Bardet-Biedl syndrome (BBS)

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