TFEB and CD47

		TFEB	CD47
Description		transcription factor EB	CD47 molecule
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane	Plasma Membrane Cell Surface Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Fibrinogen Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity
	Biological Process	Embryonic Placenta Development Adaptive Immune Response Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Autophagy Humoral Immune Response Lysosome Organization Cellular Response To Starvation Positive Regulation Of Autophagy Lysosome Localization Cellular Response To Amino Acid Starvation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Antibacterial Innate Immune Response Regulation Of Lysosome Organization	Angiogenesis Positive Regulation Of Immune System Process Apoptotic Process Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Regulation Of Type II Interferon Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Positive Regulation Of Stress Fiber Assembly Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Cell-cell Adhesion ATP Export Positive Regulation Of Monocyte Extravasation
Pathways		Transcriptional and post-translational regulation of MITF-M expression and activity Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 26965516 30529582) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Late-onset Alzheimer's disease ( 27770636) PR interval ( 32439900) White blood cell count ( 32888494)	Bipolar disorder ( 31043756 33263727 34002096) Body mass index ( 25673413) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		5 interacting genes: CFTR MITF SRPK1 TFE3 TFEC	17 interacting genes: BNIP3 EPB42 FAS GNAI1 ITGAV MTIF3 MUC1 P2RY2 PTK2 PVR RHAG SIRPA SRC SYNE4 THBS1 TMEM167B UBQLN1
Entrez ID		7942	961
HPRD ID		02847	03017
Ensembl ID		ENSG00000112561	ENSG00000196776
Uniprot IDs		B0QYS6 P19484	A0A0A1TSG4 Q08722
PDB IDs		7UX2 7UXC 7UXH 7Y62	2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU 7MYZ 7WN8 7XJF 7YGG 8RP8
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Lysosomal Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Osteoclast Differentiation Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Response To Interleukin-12 Positive Regulation Of Anion Channel Activity Melanocyte Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Monoatomic Anion Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion Response To Interleukin-12 Thrombospondin Receptor Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Monocyte Extravasation Transepithelial Water Transport ATP Export Fibrinogen Binding Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Myeloid Cell Differentiation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Response To Mechanical Stimulus Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Signaling Receptor Activity Ankyrin-1 Complex Integrin Binding Signal Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Catabolic Process Cellular Response To Hydrogen Peroxide Positive Regulation Of Phosphate Metabolic Process Regulation Of Focal Adhesion Assembly Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Cell-substrate Junction Organization Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Positive Regulation Of Fibroblast Migration Positive Regulation Of Metabolic Process Response To Hyperoxia Response To Hydrogen Peroxide Filopodium Membrane Negative Regulation Of Transport Transforming Growth Factor Beta Binding Fibroblast Growth Factor Binding Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Anoikis Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Glycolytic Process Cellular Response To Reactive Oxygen Species Cell Motility Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Chemical Stress Multicellular Organismal-level Iron Ion Homeostasis Symbiont Entry Into Host Cell Protein Autophosphorylation Positive Regulation Of Macrophage Migration Regulation Of Anoikis Autophagy Fibronectin Binding Regulation Of Cell Adhesion Extracellular Matrix Binding Regulation Of Cell-matrix Adhesion
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