TFEB

Description		transcription factor EB
Image
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Embryonic Placenta Development Adaptive Immune Response Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Autophagy Humoral Immune Response Lysosome Organization Cellular Response To Starvation Positive Regulation Of Autophagy Lysosome Localization Cellular Response To Amino Acid Starvation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Antibacterial Innate Immune Response Regulation Of Lysosome Organization
Pathways		Transcriptional and post-translational regulation of MITF-M expression and activity Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 26965516 30529582) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Late-onset Alzheimer's disease ( 27770636) PR interval ( 32439900) White blood cell count ( 32888494)
Novel Interacting Genes		6 novel interacting genes: CD47 CFTR MITF SRPK1 TFE3 TFEC
Interacting Genes		6 interacting genes: CD47 CFTR MITF SRPK1 TFE3 TFEC
Entrez ID		7942
HPRD ID		02847
Ensembl ID		ENSG00000112561
Uniprot IDs		B0QYS6 P19484
PDB IDs		7UX2 7UXC 7UXH 7Y62
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Lysosomal Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Osteoclast Differentiation Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Response To Interleukin-12 Positive Regulation Of Anion Channel Activity Melanocyte Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Monoatomic Anion Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion Response To Interleukin-12 Thrombospondin Receptor Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Monocyte Extravasation Transepithelial Water Transport ATP Export Fibrinogen Binding Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Myeloid Cell Differentiation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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