NSMCE2 and SMC5

Number of citations of the paper that reports this interaction (PubMedID 32389690)
0

Data Source:
BioGRID (biochemical, two hybrid)

		NSMCE2	SMC5
Description		NSE2 SUMO ligase component of SMC5/6 complex	structural maintenance of chromosomes 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nuclear Body PML Body Smc5-Smc6 Complex	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm PML Body Nuclear Speck Cell Junction Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity	Nucleotide Binding DNA Secondary Structure Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence Chromatin Looping	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Chromosome Segregation Protein Sumoylation Stem Cell Population Maintenance Chromosome Condensation Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Phase Transition Host-mediated Suppression Of Viral Genome Replication Chromosome Organization Cell Division Positive Regulation Of Chromosome Segregation Protein Localization To Chromosome, Centromeric Region Cellular Senescence Chromatin Looping
Pathways		SUMOylation of DNA damage response and repair proteins	SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Behcet's disease ( 33393726) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Age at first sexual intercourse ( 27089180)
Interacting Genes		5 interacting genes: ETV1 SMC5 TSNAX TXLNA USP28	6 interacting genes: CIP2A DISC1 NSMCE2 SMN1 TK1 VHL
Entrez ID		286053	23137
HPRD ID		08131	10241
Ensembl ID		ENSG00000156831	ENSG00000198887
Uniprot IDs		A0A087WTZ8 Q96MF7	Q8IY18
PDB IDs		2YU4
Enriched GO Terms of Interacting Partners?		Single-stranded DNA Binding Endoribonuclease Complex A2A Adenosine Receptor Binding DNA Secondary Structure Binding Interchromatin Granule Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Sex Chromosome Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process SiRNA Processing Smc5-Smc6 Complex
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