NSMCE2

Description		NSE2 SUMO ligase component of SMC5/6 complex
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nuclear Body PML Body Smc5-Smc6 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Metal Ion Binding SUMO Ligase Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence Chromatin Looping
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Behcet's disease ( 33393726) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Novel Interacting Genes		5 novel interacting genes: ETV1 SMC5 TSNAX TXLNA USP28
Interacting Genes		5 interacting genes: ETV1 SMC5 TSNAX TXLNA USP28
Entrez ID		286053
HPRD ID		08131
Ensembl ID		ENSG00000156831
Uniprot IDs		A0A087WTZ8 Q96MF7
PDB IDs		2YU4
Enriched GO Terms of Interacting Partners?		Single-stranded DNA Binding Endoribonuclease Complex A2A Adenosine Receptor Binding DNA Secondary Structure Binding Interchromatin Granule Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Sex Chromosome Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process SiRNA Processing Smc5-Smc6 Complex
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