MIPOL1 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
Novel	RPL10L	ribosomal protein L10 like	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	(S)-3-phenyllactic acid Anisomycin Puromycin
	AIRIM	AFG2 interacting ribosome maturation factor
	ANKRD23	ankyrin repeat domain 23
	ARNT2	aryl hydrocarbon receptor nuclear translocator 2	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes
	ATP5PO	ATP synthase peripheral stalk subunit OSCP	Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation	Artenimol
	BEX2	brain expressed X-linked 2
	BYSL	bystin like	Major pathway of rRNA processing in the nucleolus and cytosol
	C1orf35	chromosome 1 open reading frame 35	Neutrophil degranulation
	CATSPERT	catsper channel auxiliary subunit tau
	CCDC120	coiled-coil domain containing 120
	CCDC146	coiled-coil domain containing 146
	CCDC33	coiled-coil domain containing 33
	CCT3	chaperonin containing TCP1 subunit 3	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
	CDC37	cell division cycle 37, HSP90 cochaperone	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
	CDK18	cyclin dependent kinase 18
	CKS1B	CDC28 protein kinase regulatory subunit 1B	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1	Fluoxetine 2,8-bis[oxido(oxo)vanadio]-1,1,1,3,5,5,7,7,9,9,9-undecaoxopentavanadoxane-2,8-diium
	DAXX	death domain associated protein	SUMOylation of transcription cofactors Regulation of TP53 Degradation HCMV Early Events Inhibition of DNA recombination at telomere Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
	DGCR6	DiGeorge syndrome critical region gene 6
	DSCR9	Down syndrome critical region 9
	EAF1	ELL associated factor 1	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation

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