CCND1 and STAT3 |
cyclin D1 |
signal transducer and activator of transcription 3 (acute-phase response factor) |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Signaling by PDGF
- Signalling by NGF
- Signaling by FGFR in disease
- Cellular Senescence
- Interleukin-6 signaling
- Senescence-Associated Secretory Phenotype (SASP)
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Signaling by SCF-KIT
- Signaling by Interleukins
- Transcriptional regulation of pluripotent stem cells
- Downstream signal transduction
- Signaling by FGFR1 mutants
- Signalling to STAT3
- Signaling by FGFR mutants
- Signaling by FGFR1 fusion mutants
- POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
- Signaling by Leptin
- Growth hormone receptor signaling
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BAX and BCL2 |
BCL2-associated X protein |
B-cell CLL/lymphoma 2 |
- Activation, translocation and oligomerization of BAX
- Programmed Cell Death
- Intrinsic Pathway for Apoptosis
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- Activation of BAD and translocation to mitochondria
- Inflammasomes
- The NLRP1 inflammasome
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Programmed Cell Death
- Activation of BH3-only proteins
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Innate Immune System
- Intrinsic Pathway for Apoptosis
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- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
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CCND1 and CDKN1A |
cyclin D1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- Cellular Senescence
- p53-Dependent G1/S DNA damage checkpoint
- Cyclin E associated events during G1/S transition
- AKT phosphorylates targets in the cytosol
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- G1/S Transition
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Signaling by PDGF
- DAP12 interactions
- DNA Damage/Telomere Stress Induced Senescence
- GAB1 signalosome
- Senescence-Associated Secretory Phenotype (SASP)
- S Phase
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- SCF(Skp2)-mediated degradation of p27/p21
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- Adaptive Immune System
- PIP3 activates AKT signaling
- Orc1 removal from chromatin
- p53-Dependent G1 DNA Damage Response
- PI3K events in ERBB2 signaling
- Transcriptional activation of p53 responsive genes
- Downstream signaling of activated FGFR
- G1/S DNA Damage Checkpoints
- Innate Immune System
- Transcriptional activation of cell cycle inhibitor p21
- Signalling by NGF
- Synthesis of DNA
- G1 Phase
- Regulation of DNA replication
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell Cycle, Mitotic
- Signaling by FGFR
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Cell Cycle Checkpoints
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CCND1 and CDKN1B |
cyclin D1 |
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Signaling by the B Cell Receptor (BCR)
- Signaling by FGFR in disease
- Cellular Senescence
- p53-Dependent G1/S DNA damage checkpoint
- Cyclin E associated events during G1/S transition
- AKT phosphorylates targets in the cytosol
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- PI-3K cascade
- G1/S Transition
- Removal of licensing factors from origins
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Signaling by PDGF
- DAP12 interactions
- DNA Damage/Telomere Stress Induced Senescence
- GAB1 signalosome
- Senescence-Associated Secretory Phenotype (SASP)
- S Phase
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- SCF(Skp2)-mediated degradation of p27/p21
- Downstream signal transduction
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Cyclin A:Cdk2-associated events at S phase entry
- SCF(Skp2)-mediated degradation of p27/p21
- PI3K/AKT Signaling in Cancer
- Adaptive Immune System
- PIP3 activates AKT signaling
- Orc1 removal from chromatin
- p53-Dependent G1 DNA Damage Response
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- G1/S DNA Damage Checkpoints
- Innate Immune System
- Signalling by NGF
- Synthesis of DNA
- G1 Phase
- Regulation of DNA replication
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell Cycle, Mitotic
- Signaling by FGFR
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Cell Cycle Checkpoints
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CCND1 and EP300 |
cyclin D1 |
E1A binding protein p300 |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Metabolism of lipids and lipoproteins
- Signaling by Wnt
- NOTCH2 intracellular domain regulates transcription
- Regulation of gene expression by Hypoxia-inducible Factor
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Signaling by NOTCH2
- Pre-NOTCH Transcription and Translation
- RNF mutants show enhanced WNT signaling and proliferation
- Signaling by NOTCH1 in Cancer
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- Factors involved in megakaryocyte development and platelet production
- Chromatin modifying enzymes
- LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Mitotic G2-G2/M phases
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- PPARA activates gene expression
- Cellular response to hypoxia
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Attenuation phase
- G2/M Transition
- HATs acetylate histones
- RORA activates circadian gene expression
- HSF1-dependent transactivation
- TRAF3-dependent IRF activation pathway
- Signaling by NOTCH1
- Transcriptional regulation of white adipocyte differentiation
- XAV939 inhibits tankyrase, stabilizing AXIN
- Pre-NOTCH Expression and Processing
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Innate Immune System
- Fatty acid, triacylglycerol, and ketone body metabolism
- Cytosolic sensors of pathogen-associated DNA
- Cellular response to heat stress
- REV-ERBA represses gene expression
- Cell Cycle, Mitotic
- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- NOTCH1 Intracellular Domain Regulates Transcription
- TCF dependent signaling in response to WNT
- TRAF6 mediated IRF7 activation
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Signaling by WNT in cancer
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- Polo-like kinase mediated events
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CAV1 and HRAS |
caveolin 1, caveolae protein, 22kDa |
Harvey rat sarcoma viral oncogene homolog |
- Metabolism of lipids and lipoproteins
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Lipid digestion, mobilization, and transport
- Signaling by Wnt
- Basigin interactions
- VEGFA-VEGFR2 Pathway
- Cell surface interactions at the vascular wall
- eNOS activation
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Metabolism of nitric oxide
- Signaling by VEGF
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- NOSTRIN mediated eNOS trafficking
- VEGFR2 mediated vascular permeability
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Signaling by WNT in cancer
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- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- SHC-mediated cascade
- MEK activation
- FCERI mediated MAPK activation
- CREB phosphorylation through the activation of Ras
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- p38MAPK events
- EPH-Ephrin signaling
- SOS-mediated signalling
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Signalling to RAS
- Downstream signal transduction
- Signaling by FGFR mutants
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-2 signaling
- Interleukin-3, 5 and GM-CSF signaling
- Frs2-mediated activation
- Transmission across Chemical Synapses
- Ras activation uopn Ca2+ infux through NMDA receptor
- Adaptive Immune System
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- IRS-mediated signalling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- EPHB-mediated forward signaling
- IRS-related events triggered by IGF1R
- EGFR Transactivation by Gastrin
- VEGFR2 mediated cell proliferation
- GRB2 events in ERBB2 signaling
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Post NMDA receptor activation events
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- SOS-mediated signalling
- SHC-mediated signalling
- IRS-related events
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- SHC-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- ARMS-mediated activation
- SHC1 events in EGFR signaling
- RAF activation
- IRS-mediated signalling
- FRS2-mediated cascade
- Activation of RAS in B cells
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- Constitutive Signaling by EGFRvIII
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- Hexane-1,6-Diol
- Trifluoroethanol
- Guanosine-5\'-Triphosphate
- Guanosine-5\'-Diphosphate
- N,N\'-DIMETHYL-N-(ACETYL)-N\'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
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PARP1 and BCL2 |
poly (ADP-ribose) polymerase 1 |
B-cell CLL/lymphoma 2 |
- Loss of Function of TGFBR2 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- TGFBR1 LBD Mutants in Cancer
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Loss of Function of TGFBR1 in Cancer
- Generic Transcription Pathway
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
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- Activation of BAD and translocation to mitochondria
- Inflammasomes
- The NLRP1 inflammasome
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Programmed Cell Death
- Activation of BH3-only proteins
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Innate Immune System
- Intrinsic Pathway for Apoptosis
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- Carba-Nicotinamide-Adenine-Dinucleotide
- NU1025
- Nicotinamide
- 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
- 3-Methoxybenzamide
- 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
- 3,4-Dihydro-5-Methyl-Isoquinolinone
- 2-(3\'-Methoxyphenyl) Benzimidazole-4-Carboxamide
- 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
- (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium
- trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium
- 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
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- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
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CCND1 and CUL3 |
cyclin D1 |
cullin 3 |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Antigen processing: Ubiquitination & Proteasome degradation
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by Wnt
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- Hedgehog 'on' state
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by Hedgehog
- degradation of DVL
- Class I MHC mediated antigen processing & presentation
- Signaling by WNT in cancer
- Adaptive Immune System
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CCND1 and CALM1 |
cyclin D1 |
calmodulin 1 (phosphorylase kinase, delta) |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Signaling by FGFR in disease
- Phospholipase C-mediated cascade
- Signaling by Wnt
- Platelet degranulation
- Signaling by EGFRvIII in Cancer
- CREB phosphorylation through the activation of Ras
- PLCG1 events in ERBB2 signaling
- Glucose metabolism
- DAP12 signaling
- Synthesis of IP3 and IP4 in the cytosol
- Myoclonic epilepsy of Lafora
- Response to elevated platelet cytosolic Ca2+
- Glycogen storage diseases
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Activation of Ca-permeable Kainate Receptor
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Ionotropic activity of Kainate Receptors
- Signaling by PDGF
- Calmodulin induced events
- CaMK IV-mediated phosphorylation of CREB
- DAP12 interactions
- Glycogen breakdown (glycogenolysis)
- Opioid Signalling
- Activation of Kainate Receptors upon glutamate binding
- Diseases associated with visual transduction
- Inositol phosphate metabolism
- EGFR interacts with phospholipase C-gamma
- CaMK IV-mediated phosphorylation of CREB
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by VEGF
- CREB phosphorylation through the activation of CaMKK
- Downstream signal transduction
- Calmodulin induced events
- CREB phosphorylation through the activation of CaMKII
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Transcriptional activation of mitochondrial biogenesis
- Metabolism of carbohydrates
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Transmission across Chemical Synapses
- Ras activation uopn Ca2+ infux through NMDA receptor
- Organelle biogenesis and maintenance
- Cam-PDE 1 activation
- Translocation of GLUT4 to the plasma membrane
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Inactivation, recovery and regulation of the phototransduction cascade
- Metabolism of nitric oxide
- VEGFR2 mediated cell proliferation
- VEGFR2 mediated vascular permeability
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- The phototransduction cascade
- Downstream signaling of activated FGFR
- DARPP-32 events
- eNOS activation and regulation
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Post NMDA receptor activation events
- Signalling by NGF
- PLC beta mediated events
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Mitochondrial biogenesis
- beta-catenin independent WNT signaling
- Signaling by FGFR
- eNOS activation
- Cam-PDE 1 activation
- Ca2+ pathway
- Visual phototransduction
- Activation of CaMK IV
- PLC-gamma1 signalling
- FCERI mediated Ca+2 mobilization
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CCND1 and BTRC |
cyclin D1 |
beta-transducin repeat containing E3 ubiquitin protein ligase |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Signaling by the B Cell Receptor (BCR)
- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- Regulation of PLK1 Activity at G2/M Transition
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- RNF mutants show enhanced WNT signaling and proliferation
- Prolactin receptor signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- Host Interactions of HIV factors
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Regulation of APC/C activators between G1/S and early anaphase
- Signaling by ERBB4
- APC/C-mediated degradation of cell cycle proteins
- Signaling by Interleukins
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Interleukin-1 signaling
- Mitotic G2-G2/M phases
- Adaptive Immune System
- Antigen processing: Ubiquitination & Proteasome degradation
- APC truncation mutants have impaired AXIN binding
- HIV Infection
- G2/M Transition
- deactivation of the beta-catenin transactivating complex
- APC truncation mutants are not K63 polyubiquitinated
- S37 mutants of beta-catenin aren't phosphorylated
- XAV939 inhibits tankyrase, stabilizing AXIN
- Class I MHC mediated antigen processing & presentation
- Vpu mediated degradation of CD4
- Cytokine Signaling in Immune system
- Cell Cycle, Mitotic
- Nuclear signaling by ERBB4
- TCF dependent signaling in response to WNT
- Activation of NF-kappaB in B cells
- SCF-beta-TrCP mediated degradation of Emi1
- Regulation of mitotic cell cycle
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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CCND1 and PRKACA |
cyclin D1 |
protein kinase, cAMP-dependent, catalytic, alpha |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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CCND1 and FBXO4 |
cyclin D1 |
F-box protein 4 |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Protein folding
- Antigen processing: Ubiquitination & Proteasome degradation
- Chaperonin-mediated protein folding
- Association of TriC/CCT with target proteins during biosynthesis
- Class I MHC mediated antigen processing & presentation
- Adaptive Immune System
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CCND1 and MAPK11 |
cyclin D1 |
mitogen-activated protein kinase 11 |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Cellular Senescence
- Toll Like Receptor TLR1:TLR2 Cascade
- Toll Like Receptor 5 (TLR5) Cascade
- NOD1/2 Signaling Pathway
- p38MAPK events
- MyD88 dependent cascade initiated on endosome
- Toll Like Receptor 9 (TLR9) Cascade
- ERK/MAPK targets
- activated TAK1 mediates p38 MAPK activation
- Regulation of mRNA stability by proteins that bind AU-rich elements
- CDO in myogenesis
- TRIF-mediated TLR3/TLR4 signaling
- Toll Like Receptor 2 (TLR2) Cascade
- Activation of PPARGC1A (PGC-1alpha) by phosphorylation
- Myogenesis
- Signaling by VEGF
- Toll Like Receptor 4 (TLR4) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Signalling to RAS
- Signalling to ERKs
- Organelle biogenesis and maintenance
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- Toll Like Receptor TLR6:TLR2 Cascade
- VEGFA-VEGFR2 Pathway
- Activated TLR4 signalling
- Activation of the AP-1 family of transcription factors
- MyD88 cascade initiated on plasma membrane
- MyD88:Mal cascade initiated on plasma membrane
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- Innate Immune System
- Signalling by NGF
- MAP kinase activation in TLR cascade
- NGF signalling via TRKA from the plasma membrane
- MyD88-independent cascade
- Mitochondrial biogenesis
- Toll-Like Receptors Cascades
- Toll Like Receptor 10 (TLR10) Cascade
- DSCAM interactions
- Oxidative Stress Induced Senescence
- KSRP destabilizes mRNA
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- ERK/MAPK targets
- MAPK targets/ Nuclear events mediated by MAP kinases
- Nuclear Events (kinase and transcription factor activation)
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CCND1 and IFI27 |
cyclin D1 |
interferon, alpha-inducible protein 27 |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Interferon Signaling
- Cytokine Signaling in Immune system
- Interferon alpha/beta signaling
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CCND1 and ATF2 |
cyclin D1 |
activating transcription factor 2 |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Organelle biogenesis and maintenance
- Toll Like Receptor 7/8 (TLR7/8) Cascade
- HATs acetylate histones
- Toll Like Receptor TLR6:TLR2 Cascade
- Activated TLR4 signalling
- Toll Like Receptor TLR1:TLR2 Cascade
- Activation of the AP-1 family of transcription factors
- MyD88 cascade initiated on plasma membrane
- Toll Like Receptor 5 (TLR5) Cascade
- MyD88 dependent cascade initiated on endosome
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88:Mal cascade initiated on plasma membrane
- Toll Like Receptor 9 (TLR9) Cascade
- Innate Immune System
- Chromatin organization
- TRIF-mediated TLR3/TLR4 signaling
- MAP kinase activation in TLR cascade
- MyD88-independent cascade
- Mitochondrial biogenesis
- Toll Like Receptor 2 (TLR2) Cascade
- Toll-Like Receptors Cascades
- Chromatin modifying enzymes
- Toll Like Receptor 10 (TLR10) Cascade
- Toll Like Receptor 3 (TLR3) Cascade
- Toll Like Receptor 4 (TLR4) Cascade
- MAPK targets/ Nuclear events mediated by MAP kinases
- Transcriptional activation of mitochondrial biogenesis
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CCND1 and GSK3B |
cyclin D1 |
glycogen synthase kinase 3 beta |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Signaling by the B Cell Receptor (BCR)
- Hedgehog 'off' state
- Signaling by FGFR in disease
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- TCF7L2 mutants don't bind CTBP
- truncated APC mutants destabilize the destruction complex
- Signaling by Wnt
- AKT phosphorylates targets in the cytosol
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- DAP12 signaling
- Downstream signaling events of B Cell Receptor (BCR)
- Degradation of beta-catenin by the destruction complex
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Beta-catenin phosphorylation cascade
- truncations of AMER1 destabilize the destruction complex
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Signaling by EGFR
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- PI3K/AKT Signaling in Cancer
- CRMPs in Sema3A signaling
- Adaptive Immune System
- Axon guidance
- PIP3 activates AKT signaling
- APC truncation mutants have impaired AXIN binding
- APC truncation mutants are not K63 polyubiquitinated
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- S37 mutants of beta-catenin aren't phosphorylated
- PI3K events in ERBB2 signaling
- Downstream signaling of activated FGFR
- XAV939 inhibits tankyrase, stabilizing AXIN
- Innate Immune System
- Signalling by NGF
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Regulation of HSF1-mediated heat shock response
- Cellular response to heat stress
- NGF signalling via TRKA from the plasma membrane
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- TCF dependent signaling in response to WNT
- Signaling by Hedgehog
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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- Lithium
- 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
- I-5
- N-(4-Methoxybenzyl)-N\'-(5-Nitro-1,3-Thiazol-2-Yl)Urea
- Staurosporine
- Indirubin-3\'-Monoxime
- Adenosine-5\'-Diphosphate
- (3e)-6\'-Bromo-2,3\'-Biindole-2\',3(1h,1\'h)-Dione 3-Oxime
- Alsterpaullone
- Phosphoaminophosphonic Acid-Adenylate Ester
- 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
- 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
- (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
- 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2\'H-2,3\'-biindol-2\'-one
- N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
- 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
- ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
- (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
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CCND1 and HERC5 |
cyclin D1 |
HECT and RLD domain containing E3 ubiquitin protein ligase 5 |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
- Negative regulators of RIG-I/MDA5 signaling
- ISG15 antiviral mechanism
- Interferon Signaling
- Cytokine Signaling in Immune system
- Antiviral mechanism by IFN-stimulated genes
- Innate Immune System
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CCND1 and RBX1 |
cyclin D1 |
ring-box 1, E3 ubiquitin protein ligase |
- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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- Vif-mediated degradation of APOBEC3G
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Hedgehog 'off' state
- misspliced GSK3beta mutants stabilize beta-catenin
- T41 mutants of beta-catenin aren't phosphorylated
- truncated APC mutants destabilize the destruction complex
- TCF7L2 mutants don't bind CTBP
- Signaling by Wnt
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Degradation of beta-catenin by the destruction complex
- RNF mutants show enhanced WNT signaling and proliferation
- AXIN mutants destabilize the destruction complex, activating WNT signaling
- S33 mutants of beta-catenin aren't phosphorylated
- Signaling by NOTCH1 in Cancer
- Prolactin receptor signaling
- truncations of AMER1 destabilize the destruction complex
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Signaling by NOTCH
- Host Interactions of HIV factors
- phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
- AXIN missense mutants destabilize the destruction complex
- S45 mutants of beta-catenin aren't phosphorylated
- Signaling by ERBB4
- Signaling by Interleukins
- deletions in the AMER1 gene destabilize the destruction complex
- AMER1 mutants destabilize the destruction complex
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Interleukin-1 signaling
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Adaptive Immune System
- Cellular response to hypoxia
- Antigen processing: Ubiquitination & Proteasome degradation
- Regulation of Hypoxia-inducible Factor (HIF) by oxygen
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- HIV Infection
- APC truncation mutants have impaired AXIN binding
- APC truncation mutants are not K63 polyubiquitinated
- S37 mutants of beta-catenin aren't phosphorylated
- Hedgehog 'on' state
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Class I MHC mediated antigen processing & presentation
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
- FBXW7 Mutants and NOTCH1 in Cancer
- Cytokine Signaling in Immune system
- Nuclear signaling by ERBB4
- NOTCH1 Intracellular Domain Regulates Transcription
- TCF dependent signaling in response to WNT
- Signaling by Hedgehog
- deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
- Degradation of GLI1 by the proteasome
- degradation of DVL
- Signaling by WNT in cancer
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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BCL2 and PXN |
B-cell CLL/lymphoma 2 |
paxillin |
- Activation of BAD and translocation to mitochondria
- Inflammasomes
- The NLRP1 inflammasome
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Programmed Cell Death
- Activation of BH3-only proteins
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Innate Immune System
- Intrinsic Pathway for Apoptosis
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- Cell junction organization
- GAB1 signalosome
- Smooth Muscle Contraction
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Signaling by EGFRvIII in Cancer
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- VEGFA-VEGFR2 Pathway
- Signaling by EGFR
- Signaling by VEGF
- Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
- Signaling by EGFR in Cancer
- Localization of the PINCH-ILK-PARVIN complex to focal adhesions
- Cell-extracellular matrix interactions
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- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
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BCL2 and PPP1CA |
B-cell CLL/lymphoma 2 |
protein phosphatase 1, catalytic subunit, alpha isozyme |
- Activation of BAD and translocation to mitochondria
- Inflammasomes
- The NLRP1 inflammasome
- Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
- Programmed Cell Death
- Activation of BH3-only proteins
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Innate Immune System
- Intrinsic Pathway for Apoptosis
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- Loss of Function of TGFBR2 in Cancer
- Signaling by GPCR
- TGFBR2 MSI Frameshift Mutants in Cancer
- Metabolism of lipids and lipoproteins
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Opioid Signalling
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- DARPP-32 events
- SMAD4 MH2 Domain Mutants in Cancer
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- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
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