PRKACA and CCND1 |
protein kinase, cAMP-dependent, catalytic, alpha |
cyclin D1 |
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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- Chromatin organization
- Signaling by NOTCH
- Ubiquitin-dependent degradation of Cyclin D
- G1 Phase
- S Phase
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Ubiquitin-dependent degradation of Cyclin D1
- Cyclin D associated events in G1
- Chromatin modifying enzymes
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Expression and Processing
- Mitotic G1-G1/S phases
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PRKACA and ETV1 |
protein kinase, cAMP-dependent, catalytic, alpha |
ets variant 1 |
- Signaling by GPCR
- Ca-dependent events
- CaM pathway
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Metabolism of lipids and lipoproteins
- Integration of energy metabolism
- Hedgehog 'off' state
- Phospholipase C-mediated cascade
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- PLCG1 events in ERBB2 signaling
- Gluconeogenesis
- Glucose metabolism
- DAP12 signaling
- Rap1 signalling
- Myoclonic epilepsy of Lafora
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- Glycogen storage diseases
- PKA-mediated phosphorylation of key metabolic factors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Recruitment of mitotic centrosome proteins and complexes
- Glucagon signaling in metabolic regulation
- Signaling by PDGF
- Calmodulin induced events
- DAP12 interactions
- PKA-mediated phosphorylation of CREB
- Opioid Signalling
- PKA activation
- Factors involved in megakaryocyte development and platelet production
- Aquaporin-mediated transport
- CREB phosphorylation through the activation of Adenylate Cyclase
- EGFR interacts with phospholipase C-gamma
- Signaling by ERBB2
- PKA-mediated phosphorylation of CREB
- Signaling by EGFR
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Calmodulin induced events
- Signaling by EGFR in Cancer
- Metabolism of carbohydrates
- PKA activation
- Interleukin-3, 5 and GM-CSF signaling
- Mitotic G2-G2/M phases
- Transmission across Chemical Synapses
- Adaptive Immune System
- Organelle biogenesis and maintenance
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- DAG and IP3 signaling
- CaM pathway
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Loss of Nlp from mitotic centrosomes
- Downstream signaling of activated FGFR
- DARPP-32 events
- Post NMDA receptor activation events
- Innate Immune System
- PKA activation in glucagon signalling
- Signalling by NGF
- PLC beta mediated events
- Vasopressin regulates renal water homeostasis via Aquaporins
- Regulation of insulin secretion
- Cytokine Signaling in Immune system
- Assembly of the primary cilium
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Lipid digestion, mobilization, and transport
- NGF signalling via TRKA from the plasma membrane
- G-protein mediated events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- Signaling by FGFR
- Loss of proteins required for interphase microtubule organization from the centrosome
- PLC-gamma1 signalling
- Signaling by Hedgehog
- Degradation of GLI1 by the proteasome
- Centrosome maturation
- GLI3 is processed to GLI3R by the proteasome
- Degradation of GLI2 by the proteasome
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PIK3CA and SMAD2 |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
SMAD family member 2 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- TCR signaling
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
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- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Generic Transcription Pathway
- Signaling by NODAL
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Signaling by Activin
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
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SOS1 and CAV1 |
son of sevenless homolog 1 (Drosophila) |
caveolin 1, caveolae protein, 22kDa |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- SHC-mediated cascade
- FCERI mediated MAPK activation
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Regulation of KIT signaling
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- Gastrin-CREB signalling pathway via PKC and MAPK
- SOS-mediated signalling
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signalling to RAS
- Downstream signal transduction
- Signaling by Rho GTPases
- Signaling by FGFR mutants
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- Signalling to ERKs
- Axon guidance
- IRS-mediated signalling
- IGF1R signaling cascade
- Rho GTPase cycle
- IRS-related events triggered by IGF1R
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- Activation of Rac
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- NCAM signaling for neurite out-growth
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Cell death signalling via NRAGE, NRIF and NADE
- SOS-mediated signalling
- SHC-mediated signalling
- Integrin alphaIIb beta3 signaling
- p75 NTR receptor-mediated signalling
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- GRB2:SOS provides linkage to MAPK signaling for Integrins
- SHC-related events
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- SHC1 events in EGFR signaling
- FRS2-mediated cascade
- IRS-mediated signalling
- Signal attenuation
- NRAGE signals death through JNK
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Interleukin receptor SHC signaling
- FCERI mediated Ca+2 mobilization
- Constitutive Signaling by EGFRvIII
- Signaling by Robo receptor
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- Metabolism of lipids and lipoproteins
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Lipid digestion, mobilization, and transport
- Signaling by Wnt
- Basigin interactions
- VEGFA-VEGFR2 Pathway
- Cell surface interactions at the vascular wall
- eNOS activation
- disassembly of the destruction complex and recruitment of AXIN to the membrane
- Metabolism of nitric oxide
- Signaling by VEGF
- TCF dependent signaling in response to WNT
- RNF mutants show enhanced WNT signaling and proliferation
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- NOSTRIN mediated eNOS trafficking
- VEGFR2 mediated vascular permeability
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Signaling by WNT in cancer
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PIK3CA and DDX5 |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
DEAD (Asp-Glu-Ala-Asp) box helicase 5 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Signaling by FGFR1 mutants
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Constitutive PI3K/AKT Signaling in Cancer
- Role of LAT2/NTAL/LAB on calcium mobilization
- PI3K events in ERBB4 signaling
- G alpha (q) signalling events
- Signaling by ERBB2
- Signaling by EGFR
- GPCR downstream signaling
- TCR signaling
- Signaling by Interleukins
- Signaling by VEGF
- Downstream signal transduction
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- Cytokine Signaling in Immune system
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- Signaling by FGFR1 fusion mutants
- Constitutive Signaling by EGFRvIII
- PI3K Cascade
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PIK3R2 and ARRB1 |
phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
arrestin, beta 1 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- G alpha (q) signalling events
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- Signaling by Rho GTPases
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Rho GTPase cycle
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- IRS-related events
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- PI3K Cascade
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- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- Signaling by NOTCH
- Golgi Associated Vesicle Biogenesis
- Clathrin derived vesicle budding
- Lysosome Vesicle Biogenesis
- Thrombin signalling through proteinase activated receptors (PARs)
- Activated NOTCH1 Transmits Signal to the Nucleus
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Hedgehog 'on' state
- Signaling by NOTCH1
- Signaling by Hedgehog
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Signaling by NOTCH1 in Cancer
- Platelet activation, signaling and aggregation
- trans-Golgi Network Vesicle Budding
- FBXW7 Mutants and NOTCH1 in Cancer
- Activation of SMO
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PIK3R2 and TGFBR2 |
phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
transforming growth factor, beta receptor II (70/80kDa) |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- G alpha (q) signalling events
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- Signaling by Rho GTPases
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Rho GTPase cycle
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- IRS-related events
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- PI3K Cascade
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- Loss of Function of TGFBR2 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
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PIK3R2 and TGFBR1 |
phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
transforming growth factor, beta receptor 1 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Metabolism of lipids and lipoproteins
- Signaling by FGFR in disease
- Signaling by EGFRvIII in Cancer
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- PI3K/AKT activation
- Interleukin receptor SHC signaling
- PI-3K cascade
- Gastrin-CREB signalling pathway via PKC and MAPK
- Interleukin-7 signaling
- Role of phospholipids in phagocytosis
- Phospholipid metabolism
- Fcgamma receptor (FCGR) dependent phagocytosis
- PI3K Cascade
- Signaling by PDGF
- DAP12 interactions
- GAB1 signalosome
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- G alpha (q) signalling events
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by Interleukins
- TCR signaling
- Signaling by VEGF
- Signaling by Rho GTPases
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Nephrin interactions
- Interleukin-2 signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Interleukin-3, 5 and GM-CSF signaling
- Adaptive Immune System
- G alpha (q) signalling events
- Downstream TCR signaling
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- Rho GTPase cycle
- Synthesis of PIPs at the plasma membrane
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- Regulation of signaling by CBL
- Downstream signaling of activated FGFR
- G alpha (12/13) signalling events
- PI Metabolism
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- IRS-related events
- Cytokine Signaling in Immune system
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- IRS-mediated signalling
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Interleukin receptor SHC signaling
- PI3K Cascade
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- Loss of Function of TGFBR2 in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
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NRAS and SMAD4 |
neuroblastoma RAS viral (v-ras) oncogene homolog |
SMAD family member 4 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- SHC-mediated cascade
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Gastrin-CREB signalling pathway via PKC and MAPK
- p38MAPK events
- SOS-mediated signalling
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Downstream signal transduction
- Signalling to RAS
- Signaling by FGFR mutants
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-2 signaling
- Frs2-mediated activation
- Signaling by Leptin
- Adaptive Immune System
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- IRS-mediated signalling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- EGFR Transactivation by Gastrin
- GRB2 events in ERBB2 signaling
- VEGFR2 mediated cell proliferation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Insulin receptor signalling cascade
- SOS-mediated signalling
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- SHC-related events
- NGF signalling via TRKA from the plasma membrane
- Tie2 Signaling
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Cell surface interactions at the vascular wall
- Signaling by FGFR
- ARMS-mediated activation
- RAF activation
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- Activation of RAS in B cells
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- Constitutive Signaling by EGFRvIII
|
- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by BMP
- Transcriptional regulation of pluripotent stem cells
- Generic Transcription Pathway
- Signaling by NODAL
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Signaling by Activin
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
|
|
|
|
|
RAF1 and MYC |
Raf-1 proto-oncogene, serine/threonine kinase |
v-myc avian myelocytomatosis viral oncogene homolog |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- CREB phosphorylation through the activation of Ras
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Rap1 signalling
- Gastrin-CREB signalling pathway via PKC and MAPK
- SOS-mediated signalling
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- GP1b-IX-V activation signalling
- Signaling by VEGF
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Transmission across Chemical Synapses
- Adaptive Immune System
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- IRS-mediated signalling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- Ion channel transport
- GRB2 events in ERBB2 signaling
- VEGFR2 mediated cell proliferation
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- Stimuli-sensing channels
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Post NMDA receptor activation events
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- SOS-mediated signalling
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- RAF activation
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Signaling by Wnt
- Cyclin E associated events during G1/S transition
- binding of TCF/LEF:CTNNB1 to target gene promoters
- TGFBR1 LBD Mutants in Cancer
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- G1/S Transition
- Signaling by NOTCH1
- XAV939 inhibits tankyrase, stabilizing AXIN
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Mitotic G1-G1/S phases
- FBXW7 Mutants and NOTCH1 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- Signaling by NOTCH
- formation of the beta-catenin:TCF transactivating complex
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- S Phase
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- NOTCH1 Intracellular Domain Regulates Transcription
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- TCF dependent signaling in response to WNT
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Cyclin A:Cdk2-associated events at S phase entry
- Signaling by WNT in cancer
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- SMAD4 MH2 Domain Mutants in Cancer
|
- Sorafenib
- Regorafenib
- Dabrafenib
|
|
|
|
YWHAB and HIST1H3A |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
histone cluster 1, H3a |
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- MEK activation
- FCERI mediated MAPK activation
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Rap1 signalling
- Gastrin-CREB signalling pathway via PKC and MAPK
- SOS-mediated signalling
- SHC-mediated signalling
- Signaling by PDGF
- Regulation of mRNA stability by proteins that bind AU-rich elements
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- Signaling by VEGF
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-2 signaling
- Frs2-mediated activation
- Adaptive Immune System
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- IRS-mediated signalling
- Translocation of GLUT4 to the plasma membrane
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- GRB2 events in ERBB2 signaling
- VEGFR2 mediated cell proliferation
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- Programmed Cell Death
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- SOS-mediated signalling
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Tristetraprolin (TTP) destabilizes mRNA
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- Signaling by Hippo
- RAF activation
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
- RNA Polymerase I Chain Elongation
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Mitotic Prophase
- PKMTs methylate histone lysines
- Regulatory RNA pathways
- RNA Polymerase I Promoter Clearance
- HDMs demethylate histones
- Cellular Senescence
- Signaling by Wnt
- HATs acetylate histones
- M Phase
- Amyloids
- NoRC negatively regulates rRNA expression
- RNF mutants show enhanced WNT signaling and proliferation
- XAV939 inhibits tankyrase, stabilizing AXIN
- DNA methylation
- Transcriptional regulation by small RNAs
- Meiotic recombination
- HDACs deacetylate histones
- Chromatin organization
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- RNA Polymerase I Transcription
- formation of the beta-catenin:TCF transactivating complex
- Epigenetic regulation of gene expression
- Senescence-Associated Secretory Phenotype (SASP)
- Negative epigenetic regulation of rRNA expression
- Factors involved in megakaryocyte development and platelet production
- PRC2 methylates histones and DNA
- Cell Cycle, Mitotic
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- Oxidative Stress Induced Senescence
- TCF dependent signaling in response to WNT
- RNA Polymerase I Promoter Opening
- SIRT1 negatively regulates rRNA Expression
- Signaling by WNT in cancer
- Condensation of Prophase Chromosomes
|
|
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AKT1 and NCOR2 |
v-akt murine thymoma viral oncogene homolog 1 |
nuclear receptor corepressor 2 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
|
- Loss of Function of TGFBR2 in Cancer
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- Metabolism of lipids and lipoproteins
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- Signaling by NOTCH1
- Transcriptional regulation of white adipocyte differentiation
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- Fatty acid, triacylglycerol, and ketone body metabolism
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Chromatin organization
- HDACs deacetylate histones
- Loss of Function of SMAD2/3 in Cancer
- Signaling by NOTCH
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- NOTCH1 Intracellular Domain Regulates Transcription
- Chromatin modifying enzymes
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- SMAD4 MH2 Domain Mutants in Cancer
|
- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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|
|
|
AKT1 and PPM1A |
v-akt murine thymoma viral oncogene homolog 1 |
protein phosphatase, Mg2+/Mn2+ dependent, 1A |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
|
- Loss of Function of TGFBR2 in Cancer
- IRS-mediated signalling
- mTOR signalling
- SMAD2/3 MH2 Domain Mutants in Cancer
- mTOR signalling
- TGFBR1 LBD Mutants in Cancer
- IGF1R signaling cascade
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- IRS-related events triggered by IGF1R
- Generic Transcription Pathway
- Energy dependent regulation of mTOR by LKB1-AMPK
- PKB-mediated events
- PI3K Cascade
- Signaling by Insulin receptor
- TGFBR2 MSI Frameshift Mutants in Cancer
- Insulin receptor signalling cascade
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Regulation of AMPK activity via LKB1
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- IRS-related events
- Loss of Function of TGFBR1 in Cancer
- IRS-mediated signalling
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- PKB-mediated events
- PI3K Cascade
- SMAD4 MH2 Domain Mutants in Cancer
|
- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
|
|
|
|
RAF1 and PPP1CC |
Raf-1 proto-oncogene, serine/threonine kinase |
protein phosphatase 1, catalytic subunit, gamma isozyme |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- CREB phosphorylation through the activation of Ras
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Rap1 signalling
- Gastrin-CREB signalling pathway via PKC and MAPK
- SOS-mediated signalling
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- GP1b-IX-V activation signalling
- Signaling by VEGF
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Transmission across Chemical Synapses
- Adaptive Immune System
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- IRS-mediated signalling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- Ion channel transport
- GRB2 events in ERBB2 signaling
- VEGFR2 mediated cell proliferation
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- Stimuli-sensing channels
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Post NMDA receptor activation events
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- SOS-mediated signalling
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- RAF activation
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
- Loss of Function of TGFBR2 in Cancer
- Mitotic Prometaphase
- Metabolism of lipids and lipoproteins
- Separation of Sister Chromatids
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- Mitotic Anaphase
- TGFBR1 LBD Mutants in Cancer
- M Phase
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- Cell Cycle, Mitotic
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- Resolution of Sister Chromatid Cohesion
- Mitotic Metaphase and Anaphase
- SMAD4 MH2 Domain Mutants in Cancer
|
- Sorafenib
- Regorafenib
- Dabrafenib
|
- 9,10-Deepithio-9,10-Didehydroacanthifolicin
- Calyculin A
- (2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACID
- Motuporin
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|
|
AKT1 and KAT2B |
v-akt murine thymoma viral oncogene homolog 1 |
K(lysine) acetyltransferase 2B |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
|
- Signaling by NOTCH1 HD Domain Mutants in Cancer
- RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
- Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Clearance
- HATs acetylate histones
- Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
- Generic Transcription Pathway
- Pre-NOTCH Transcription and Translation
- Signaling by NOTCH1
- Pre-NOTCH Expression and Processing
- Signaling by NOTCH1 in Cancer
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- FBXW7 Mutants and NOTCH1 in Cancer
- Chromatin organization
- RNA Polymerase I Transcription
- Signaling by NOTCH
- Notch-HLH transcription pathway
- NOTCH1 Intracellular Domain Regulates Transcription
- Chromatin modifying enzymes
- Signaling by NOTCH1 PEST Domain Mutants in Cancer
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
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- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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RAF1 and RB1 |
Raf-1 proto-oncogene, serine/threonine kinase |
retinoblastoma 1 |
- Signaling by GPCR
- Signaling by FGFR in disease
- MEK activation
- FCERI mediated MAPK activation
- CREB phosphorylation through the activation of Ras
- Signaling by EGFRvIII in Cancer
- SHC1 events in ERBB2 signaling
- Signaling by SCF-KIT
- DAP12 signaling
- Rap1 signalling
- Gastrin-CREB signalling pathway via PKC and MAPK
- SOS-mediated signalling
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- SHC-mediated signalling
- Signaling by PDGF
- DAP12 interactions
- SHC-related events triggered by IGF1R
- GRB2 events in EGFR signaling
- Signaling by ERBB4
- Signaling by ERBB2
- Signaling by EGFR
- Signaling by Interleukins
- SHC1 events in ERBB4 signaling
- GP1b-IX-V activation signalling
- Signaling by VEGF
- Signalling to RAS
- Downstream signal transduction
- Fc epsilon receptor (FCERI) signaling
- Signaling by EGFR in Cancer
- Interleukin-2 signaling
- Platelet activation, signaling and aggregation
- Frs2-mediated activation
- Transmission across Chemical Synapses
- Adaptive Immune System
- Signaling by Leptin
- Signalling to ERKs
- Prolonged ERK activation events
- Axon guidance
- IRS-mediated signalling
- IGF1R signaling cascade
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- Ion channel transport
- GRB2 events in ERBB2 signaling
- VEGFR2 mediated cell proliferation
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- RAF phosphorylates MEK
- Downstream signaling of activated FGFR
- Stimuli-sensing channels
- NCAM signaling for neurite out-growth
- RAF/MAP kinase cascade
- Signalling to p38 via RIT and RIN
- Post NMDA receptor activation events
- Innate Immune System
- Signaling by Insulin receptor
- Signalling by NGF
- Insulin receptor signalling cascade
- SOS-mediated signalling
- SHC-mediated signalling
- Cytokine Signaling in Immune system
- IRS-related events
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- SHC-related events
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- ARMS-mediated activation
- RAF activation
- SHC1 events in EGFR signaling
- IRS-mediated signalling
- FRS2-mediated cascade
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
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- E2F mediated regulation of DNA replication
- DNA Damage/Telomere Stress Induced Senescence
- Synthesis of DNA
- Mitotic Prophase
- Cellular Senescence
- G1 Phase
- Regulation of DNA replication
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Orc1 removal from chromatin
- S Phase
- Cyclin E associated events during G1/S transition
- Cell Cycle, Mitotic
- M Phase
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Formation of Senescence-Associated Heterochromatin Foci (SAHF)
- G1/S Transition
- Removal of licensing factors from origins
- Cyclin A:Cdk2-associated events at S phase entry
- Switching of origins to a post-replicative state
- Mitotic G1-G1/S phases
- Condensation of Prophase Chromosomes
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
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- Sorafenib
- Regorafenib
- Dabrafenib
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AKT1 and SMAD4 |
v-akt murine thymoma viral oncogene homolog 1 |
SMAD family member 4 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
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- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by BMP
- Transcriptional regulation of pluripotent stem cells
- Generic Transcription Pathway
- Signaling by NODAL
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Signaling by Activin
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
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- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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AKT1 and PPP1CA |
v-akt murine thymoma viral oncogene homolog 1 |
protein phosphatase 1, catalytic subunit, alpha isozyme |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
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- Loss of Function of TGFBR2 in Cancer
- Signaling by GPCR
- TGFBR2 MSI Frameshift Mutants in Cancer
- Metabolism of lipids and lipoproteins
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Opioid Signalling
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Lipid digestion, mobilization, and transport
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
- DARPP-32 events
- SMAD4 MH2 Domain Mutants in Cancer
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- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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AKT1 and SMAD2 |
v-akt murine thymoma viral oncogene homolog 1 |
SMAD family member 2 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
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- Loss of Function of TGFBR2 in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGFBR1 LBD Mutants in Cancer
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Generic Transcription Pathway
- Signaling by NODAL
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- Signaling by Activin
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by TGF-beta Receptor Complex
- SMAD4 MH2 Domain Mutants in Cancer
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- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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AKT1 and PRKCZ |
v-akt murine thymoma viral oncogene homolog 1 |
protein kinase C, zeta |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
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- Loss of Function of TGFBR2 in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- VEGFA-VEGFR2 Pathway
- VEGFR2 mediated cell proliferation
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- Signaling by VEGF
- GPVI-mediated activation cascade
- Platelet activation, signaling and aggregation
- SMAD4 MH2 Domain Mutants in Cancer
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- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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