TOMM70 and OR5K4

		TOMM70	OR5K4
Description		translocase of outer mitochondrial membrane 70	olfactory receptor family 5 subfamily K member 4
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondrial Membrane Extracellular Exosome TOM Complex	Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Molecular Adaptor Activity	G Protein-coupled Receptor Activity Olfactory Receptor Activity Odorant Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion MRNA Transcription Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Response To Thyroxine Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Protein Targeting To Mitochondrion	Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell
Pathways		Mitochondrial protein import DDX58/IFIH1-mediated induction of interferon-alpha/beta PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Expression and translocation of olfactory receptors
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 OGT PINK1 PRKN SNAPIN
Entrez ID		9868	403278
HPRD ID		16194	17764
Ensembl ID		ENSG00000154174	ENSG00000196098
Uniprot IDs		O94826	A6NMS3
PDB IDs		7DHG 7KDT
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Protein Refolding Regulation Of Protein Ubiquitination Lysosomal Transport Regulation Of Post-translational Protein Modification Protein Folding Chaperone Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Vacuolar Transport Positive Regulation Of Gene Expression Positive Regulation Of Protein Polymerization Regulation Of Proteasomal Protein Catabolic Process Intracellular Transport Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Negative Regulation Of Cellular Component Organization Aggresome Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Hydrogen Sulfide ATP-dependent Protein Folding Chaperone Mitochondrial Transport Regulation Of Programmed Cell Death Histone Deacetylase Binding Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Cellular Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Localization In Cell Ubiquitin Protein Ligase Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Response To Temperature Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Heat Cytosol Positive Regulation Of Microtubule Nucleation Mitophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process	Response To Thyroxine Protein Import Into Mitochondrial Matrix Protein Transmembrane Transporter Activity Positive Regulation Of Defense Response To Virus By Host Protein Insertion Into Mitochondrial Inner Membrane Negative Regulation Of Muscle Hypertrophy Protein Targeting To Mitochondrion Protein Localization To Mitochondrion TOM Complex Protein Insertion Into Mitochondrial Outer Membrane Mitochondrion Targeting Sequence Binding Establishment Of Protein Localization To Mitochondrial Membrane Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Response To Thyroid Hormone Negative Regulation Of Organ Growth Response To L-phenylalanine Derivative Positive Regulation Of Interferon-beta Production Mitochondrial Outer Membrane Translocase Complex Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Inner Mitochondrial Membrane Organization Negative Regulation Of Cardiac Muscle Tissue Growth Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Cardiac Muscle Hypertrophy Protein Insertion Into Mitochondrial Membrane Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Protein Targeting To Mitochondrion Regulation Of Defense Response To Virus By Host Protein Transmembrane Transport Establishment Of Protein Localization To Mitochondrion Regulation Of Heart Growth Antiviral Innate Immune Response MRNA Transcription Regulation Of Defense Response To Virus Protein Insertion Into Membrane Cellular Response To Virus Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Regulation Of Interferon-beta Production Positive Regulation Of Type I Interferon Production Regulation Of Striated Muscle Cell Differentiation Regulation Of Organ Growth Negative Regulation Of Developmental Growth Mitochondrial Membrane Organization Response To Amino Acid Regulation Of Type I Interferon Production Regulation Of Muscle Cell Differentiation Negative Regulation Of Cell Growth Mitochondrial Membrane Molecular Adaptor Activity
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