TOMM70 and DCBLD2

		TOMM70	DCBLD2
Description		translocase of outer mitochondrial membrane 70	discoidin, CUB and LCCL domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondrial Membrane Extracellular Exosome TOM Complex	Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Mitochondrion Targeting Sequence Binding Molecular Adaptor Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Protein Targeting To Mitochondrion MRNA Transcription Protein Import Into Mitochondrial Matrix Positive Regulation Of Interferon-beta Production Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Inner Membrane Protein Insertion Into Mitochondrial Outer Membrane Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Response To Thyroxine Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Wound Healing
Pathways		Mitochondrial protein import DDX58/IFIH1-mediated induction of interferon-alpha/beta PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS			Childhood ear infection ( 27182965) FEV1 ( 30804560) Height ( 31562340) Heschl's gyrus morphology ( 25130324) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30061609) Lung function (FVC) ( 30061609 30804560) Metabolite levels ( 23823483) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		9 interacting genes: HSP90AA1 HSPA1A HSPA1B HSPB1 IRF3 OGT PINK1 PRKN SNAPIN	8 interacting genes: EGFR GDAP1 MALL REEP4 SLC60A2 SLC7A14 TIMMDC1 TSPAN2
Entrez ID		9868	131566
HPRD ID		16194	10567
Ensembl ID		ENSG00000154174	ENSG00000057019
Uniprot IDs		O94826	B7Z7Y3 Q96PD2
PDB IDs		7DHG 7KDT
Enriched GO Terms of Interacting Partners?		C3HC4-type RING Finger Domain Binding Protein Refolding Regulation Of Protein Ubiquitination Lysosomal Transport Regulation Of Post-translational Protein Modification Protein Folding Chaperone Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Vacuolar Transport Positive Regulation Of Gene Expression Positive Regulation Of Protein Polymerization Regulation Of Proteasomal Protein Catabolic Process Intracellular Transport Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Regulation Of Protein Modification Process Mitochondrion To Lysosome Vesicle-mediated Transport Cellular Response To Hydrogen Sulfide Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Negative Regulation Of Cellular Component Organization Aggresome Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Unfolded Protein Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Hydrogen Sulfide ATP-dependent Protein Folding Chaperone Mitochondrial Transport Regulation Of Programmed Cell Death Histone Deacetylase Binding Negative Regulation Of Mitochondrial Fission Regulation Of Synaptic Vesicle Transport Cellular Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Establishment Of Localization In Cell Ubiquitin Protein Ligase Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Lewy Body Response To Temperature Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Heat Cytosol Positive Regulation Of Microtubule Nucleation Mitophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process
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