ABCC3 and PKD1L1

		ABCC3	PKD1L1
Description		ATP binding cassette subfamily C member 3	polycystin 1 like 1, transient receptor potential channel interacting
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Ciliary Basal Body	Plasma Membrane Cilium Membrane Calcium Channel Complex Cell Projection Ciliary Membrane Non-motile Cilium
	Molecular Function	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity Glucuronoside Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ABC-type Bile Acid Transporter Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Icosanoid Transmembrane Transporter Activity ABC-type Transporter Activity	Calcium Channel Activity Protein Binding
	Biological Process	Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Bile Acid And Bile Salt Transport Glucuronoside Transport Xenobiotic Transport Carboxylic Acid Transport Transmembrane Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Transport Across Blood-brain Barrier	Detection Of Nodal Flow Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Detection Of Mechanical Stimulus Calcium Ion Transmembrane Transport Left/right Axis Specification Cell-cell Adhesion
Pathways		Recycling of bile acids and salts ABC-family proteins mediated transport Aspirin ADME Paracetamol ADME NFE2L2 regulating MDR associated enzymes
Drugs
Diseases
GWAS			Anxiety disorder ( 25390645) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Gut microbiota alpha diversity (Shannon index) ( 33208821) Hepatitis C induced liver fibrosis ( 22841784) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		2 interacting genes: MLH1 MTDH	1 interacting genes: CLK1
Entrez ID		8714	168507
HPRD ID		06826	10154
Ensembl ID		ENSG00000108846	ENSG00000158683
Uniprot IDs		O15438 Q86VN9	Q8TDX9
PDB IDs		8HVH 8HW2 8HW4 8IZP
Enriched GO Terms of Interacting Partners?		Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation Homologous Chromosome Segregation MutLalpha Complex Female Meiosis Chromosome Segregation Chiasma Late Recombination Nodule Mismatch Repair Complex Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Common Bile Duct Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Smoothened Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Detection Of Nodal Flow Positive Regulation Of Isotype Switching To IgA Isotypes Intercellular Canaliculus MutSalpha Complex Binding Regulation Of Mitotic Recombination Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Spindle Midzone Assembly Somatic Diversification Of Immune Receptors Via Somatic Mutation MKS Complex Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Left/right Axis Specification Regulation Of Isotype Switching To IgG Isotypes	Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity G-protein Beta/gamma-subunit Complex ATPase-coupled Transmembrane Transporter Activity Icosanoid Transmembrane Transporter Activity ABC-type Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport Ciliary Basal Body
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