RFXANK and STOML2

		RFXANK	STOML2
Description		regulatory factor X associated ankyrin containing protein	stomatin like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intercellular Bridge RNA Polymerase II Transcription Regulator Complex	Immunological Synapse Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Membrane Raft
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding	Protein Binding Lipid Binding T Cell Receptor Binding GTPase Binding Cardiolipin Binding
	Biological Process	Ras Protein Signal Transduction Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II	Intracellular Calcium Ion Homeostasis Mitochondrion Organization Lipid Localization Positive Regulation Of Interleukin-2 Production Mitochondrial Protein Processing CD4-positive, Alpha-beta T Cell Activation Proton Motive Force-driven Mitochondrial ATP Synthesis T Cell Receptor Signaling Pathway Protein Complex Oligomerization Stress-induced Mitochondrial Fusion
Pathways			Processing of SMDT1 Cellular response to mitochondrial stress
Drugs
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CIITA HDAC4 HDAC5 RAF1 RFX5 RFXAP	5 interacting genes: APP GLP1R OGT RABAC1 SUMO4
Entrez ID		8625	30968
HPRD ID		04435	16310
Ensembl ID		ENSG00000064490	ENSG00000165283
Uniprot IDs		A0A024R7P0 O14593	A0A087WYB4 Q9UJZ1
PDB IDs		3UXG 3V30 6MEW
Enriched GO Terms of Interacting Partners?		Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Interferon-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of RNA Metabolic Process Protein Lysine Deacetylase Activity Type II Interferon-mediated Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of RNA Metabolic Process Lipid Localization Cytokine-mediated Signaling Pathway Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Striated Muscle Cell Differentiation Lymphocyte Activation Death-inducing Signaling Complex Assembly Stress-induced Mitochondrial Fusion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process B Cell Differentiation Leukocyte Activation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Regulation Of Muscle Cell Differentiation Cell Activation Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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