CADPS and FEZF2

		CADPS	FEZF2
Description		calcium dependent secretion activator	FEZ family zinc finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane Cytoplasmic Vesicle Synapse Presynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Membrane	Nucleus
	Molecular Function	Protein Binding Lipid Binding Protein Kinase Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Exocytosis Protein Transport Synaptic Vesicle Exocytosis Positive Regulation Of Exocytosis Dense Core Granule Exocytosis	Negative Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonal Fasciculation Locomotory Behavior Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Dendrite Development Telencephalon Development Dentate Gyrus Development Forebrain Anterior/posterior Pattern Specification Cerebral Cortex GABAergic Interneuron Migration Cerebral Cortex Neuron Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Differentiation Cell Differentiation Neuron Differentiation Forebrain Development Cell Dedifferentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Determination Regulation Of Neurogenesis GABAergic Neuron Differentiation Regulation Of Axon Guidance
Pathways
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder ( 30804558) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast size ( 22747683 27182965) Cigarettes smoked per day in Schizophrenia ( 33691233) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Daytime nap ( 33568662) Economic and political preferences (environmentalism) ( 22566634) Fasting plasma glucose ( 31932636) Hand grip strength ( 29691431) Lung function (FEV1/FVC) ( 30061609) Meat-related diet ( 32066663) Metabolite levels (X-11787) ( 23934736) Obsessive-compulsive symptoms ( 26859814) Optic disc size ( 31809533) Pre-treatment viral load in HIV-1 infection ( 31219150) Processed meat consumption ( 32066663) QT interval (sulfonylurea treatment interaction) ( 27958378) Risk-taking tendency (4-domain principal component model) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Trunk fat mass ( 28552196)	Age at first sexual intercourse ( 34211149) Metabolite levels ( 23823483)
Interacting Genes		45 interacting genes: ACTN3 ANKS1A AURKC C17orf67 CABP5 CCDC120 CCDC185 DMD DNAJC5 DRD2 DSCAM FAM161A FAM90A1 FAM9B FANCL FOXD2 GADD45GIP1 GPANK1 GSE1 HDAC4 HOXB5 HOXC8 KANK2 KIAA1549 LNX1 LUC7L2 OLIG3 PIP5K1A PNMA5 PRPF18 SDCBP SEC23A SH2D4A SHFL TCL1A TENT2 TRIM55 TRIM63 TSEN2 TTC3 TTLL10 USP2 ZFC3H1 ZNF572 ZNF688	1 interacting genes: APP
Entrez ID		8618	55079
HPRD ID		05236	07596
Ensembl ID		ENSG00000163618	ENSG00000153266
Uniprot IDs		F1T0E5 Q9ULU8	A0A140VKG3 Q8TBJ5
PDB IDs		1WI1
Enriched GO Terms of Interacting Partners?		Response To Inactivity Negative Regulation Of Glycolytic Process Negative Regulation Of ATP Metabolic Process Skeletal Muscle Atrophy Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Adaptation Striated Muscle Atrophy Cerebral Cortex GABAergic Interneuron Migration Interneuron Migration From The Subpallium To The Cortex Response To Muscle Inactivity Muscle Atrophy Regulation Of Glycolytic Process Interneuron Migration Muscle System Process Regulation Of Carbohydrate Catabolic Process	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Presynapse Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Neuronal Dense Core Vesicle Membrane Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Dense Core Granule Exocytosis Peptidase Activator Activity Cellular Response To Manganese Ion Regulation Of Vesicle-mediated Transport Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
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