QRFPR and BBS7

		QRFPR	BBS7
Description		pyroglutamylated RFamide peptide receptor	Bardet-Biedl syndrome 7
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Photoreceptor Outer Segment Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane
	Molecular Function	G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Protein Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cellular Response To Hormone Stimulus	Eye Development Heart Looping Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Determination Of Left/right Symmetry Brain Development Heart Development Visual Perception Intracellular Protein Localization Protein Transport Cell Projection Organization Melanosome Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Intracellular Transport Digestive Tract Morphogenesis Pigment Granule Aggregation In Cell Center Limb Development Cilium Assembly Primary Palate Development Non-motile Cilium Assembly
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Weight ( 34074324)	Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172) Psoriasis ( 31376382)
Interacting Genes		2 interacting genes: GJA8 NTM	4 interacting genes: FHOD1 JUN KRT18 PAX2
Entrez ID		84109	55212
HPRD ID		09494	07399
Ensembl ID		ENSG00000186867	ENSG00000138686
Uniprot IDs		F2Z3L3 Q96P65	Q8IWZ6
PDB IDs		8WZ2 8ZH8
Enriched GO Terms of Interacting Partners?		Eye Development Fat Cell Differentiation Pigment Granule Aggregation In Cell Center Primary Palate Development Sensory Organ Development Gap Junction-mediated Intercellular Transport BBSome Intercellular Transport	Establishment Of Centrosome Localization Negative Regulation Of Programmed Cell Death Endothelial Microparticle Signal Transduction Negative Regulation Of Apoptotic Process Meiotic Mismatch Repair Single Thymine Insertion Binding MutSalpha Complex Response To Light Stimulus Leading Edge Cell Differentiation Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Centrosome Localization Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Regulation Of Metanephros Size Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Optic Cup Morphogenesis Involved In Camera-type Eye Development Calcium Channel Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Guanine/thymine Mispair Binding Single Guanine Insertion Binding Response To Anisomycin Cellular Response To Anisomycin Microtubule Organizing Center Mitotic Checkpoint Complex Vestibulocochlear Nerve Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Nephric Duct Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ureter Maturation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Operant Conditioning Intracellular Cyclic Nucleotide Activated Cation Channel Complex Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Intracellularly CGMP-activated Cation Channel Activity Double-stranded DNA Binding Response To Radiation Release From Viral Latency Transcription Factor AP-1 Complex Response To Calcium Ion Centriolar Satellite
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