MIXL1 and DNAH14

		MIXL1	DNAH14
Description		Mix paired-like homeobox	dynein axonemal heavy chain 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Cytoplasm Cytoskeleton Microtubule Cilium Dynein Complex Cell Projection 9+2 Motile Cilium
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Identical Protein Binding Protein Homodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Endoderm Formation Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Endoderm Development Heart Development Hemopoiesis Cell Differentiation Endodermal Cell Differentiation Cell Migration Involved In Gastrulation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Mesoderm Development	Microtubule-based Movement Cilium Movement Involved In Cell Motility
Pathways		Germ layer formation at gastrulation Formation of definitive endoderm
Drugs
Diseases
GWAS			Adult body size ( 32376654) Copper levels ( 26025379) Delirium ( 29631748) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377)
Interacting Genes			2 interacting genes: APP FBXO7
Entrez ID		83881	127602
HPRD ID		10086	19478
Ensembl ID		ENSG00000185155	ENSG00000185842
Uniprot IDs		Q9H2W2	A0A804HLD3 M9MMK7 Q0VDD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Dynein Intermediate Chain Binding 9+2 Motile Cilium Minus-end-directed Microtubule Motor Activity Dynein Light Intermediate Chain Binding Dynein Complex Cilium Movement Involved In Cell Motility Cilium Movement Microtubule Microtubule-based Movement	Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Cell Cycle G1/S Phase Transition Glial Cytoplasmic Inclusion Classical Lewy Body Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Mitotic Cell Cycle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Surfactant Secretion Lewy Body Core Positive Regulation Of Mesoderm Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Osmolarity-sensing Monoatomic Cation Channel Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Hemopoiesis Regulation Of Toll Signaling Pathway
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