CD276 and ACSBG1

		CD276	ACSBG1
Description		CD276 molecule	acyl-CoA synthetase bubblegum family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	External Side Of Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Signaling Receptor Binding Protein Binding	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Ligase Activity Very Long-chain Fatty Acid-CoA Ligase Activity
	Biological Process	Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Type II Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Immune Response T Cell Receptor Signaling Pathway	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Myelination Long-chain Fatty Acid Biosynthetic Process Response To Glucocorticoid
Pathways			Synthesis of very long-chain fatty acyl-CoAs
Drugs		Omburtamab	2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-1,3-THIAZOL-4(5H)-ONE
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bipolar disorder ( 21738484 31043756) Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications ( 28100913) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Tourette syndrome ( 30818990)	Diffusing capacity of carbon monoxide ( 30694715) Eyebrow thickness ( 26926045) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Personality dimensions ( 20691247) Red cell distribution width ( 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes			2 interacting genes: APP GSK3B
Entrez ID		80381	23205
HPRD ID		05756	16549
Ensembl ID		ENSG00000103855	ENSG00000103740
Uniprot IDs		A0A0C4DGH0 A8K9J6 Q5ZPR3	B3KNS7 B7Z2Y6 Q96GR2
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Protein Localization To Nucleus Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Cellular Response To Amyloid-beta Response To Amyloid-beta Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Type II Interferon Production Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Type II Interferon Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Gene Expression Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Neuron Differentiation Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Protein Localization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Regulation Of Protein Localization To Nucleus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Presynapse Postsynapse Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuron Apoptotic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus
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