TARS2 and CIART

		TARS2	CIART
Description		threonyl-tRNA synthetase 2, mitochondrial	circadian associated repressor of transcription
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Nucleus PML Body
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Threonine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Homodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding E-box Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Threonyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	Circadian Regulation Of Gene Expression Locomotor Rhythm Negative Regulation Of DNA-templated Transcription Rhythmic Process
Pathways		Mitochondrial tRNA aminoacylation
Drugs		Threonine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Plateletcrit ( 32888494) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: ARL6IP1 ASB6 FKBP7 HOMEZ PLIN3 SLC17A9 SYPL1 TARS3 TNFRSF10D	3 interacting genes: APP DAB1 NFYC
Entrez ID		80222	148523
HPRD ID		18148	14081
Ensembl ID		ENSG00000143374	ENSG00000159208
Uniprot IDs		Q9BW92 U3KQG0	Q5TB12 Q8N365 Q8WVX4
PDB IDs
Enriched GO Terms of Interacting Partners?			Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Adult Locomotory Behavior Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Neuron Differentiation Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Neuron Differentiation Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Dendrite Development Positive Regulation Of Protein Import Locomotory Behavior Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Axonogenesis Lateral Motor Column Neuron Migration Cerebellum Structural Organization Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Radial Glia Guided Migration Of Purkinje Cell Mitochondrial Threonyl-tRNA Aminoacylation Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Spinal Cord Motor Neuron Migration Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon CCAAT-binding Factor Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Neuron Projection Morphogenesis Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Radial Glia-guided Pyramidal Neuron Migration Cell Projection Morphogenesis
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