SETD6 and PRSS54

		SETD6	PRSS54
Description		SET domain containing 6, protein lysine methyltransferase	serine protease 54
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity NF-kappaB Binding S-adenosyl-L-methionine Binding	Serine-type Endopeptidase Activity
	Biological Process	Peptidyl-lysine Monomethylation Stem Cell Population Maintenance Negative Regulation Of NF-kappaB Transcription Factor Activity Methylation Stem Cell Differentiation Regulation Of Inflammatory Response	Proteolysis
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure ( 30578418) QT interval ( 29213071) Schizophrenia ( 29483656)	Alcohol dependence ( 26365420) Systemic lupus erythematosus ( 26502338)
Interacting Genes		1 interacting genes: ATXN1
Entrez ID		79918	221191
HPRD ID		07956	19051
Ensembl ID		ENSG00000103037	ENSG00000103023
Uniprot IDs		Q8TBK2	A0A140VKC3 F5H6C6 Q6PEW0
PDB IDs		3QXY 3RC0
Enriched GO Terms of Interacting Partners?		Poly(G) Binding POZ Domain Binding Nuclear Inclusion Body Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Detection Of Molecule Of Bacterial Origin Positive Regulation Of Gamma-delta T Cell Activation Detection Of Bacterium Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Detection Of Muramyl Dipeptide Detection Of Peptidoglycan Intestinal Stem Cell Homeostasis Cellular Response To Peptidoglycan Protein Linear Polyubiquitination Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Carbohydrate Derivative Binding Extrinsic Component Of Plasma Membrane Cellular Response To Muramyl Dipeptide Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Dendritic Cell Cytokine Production Response To Peptidoglycan Muramyl Dipeptide Binding Anion Binding Host-mediated Modulation Of Intestinal Microbiota Composition CMG Complex GINS Complex Regulation Of Protein K63-linked Ubiquitination CARD Domain Binding Peptidoglycan Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Type 2 Immune Response Positive Regulation Of Protein Polyubiquitination Antibacterial Innate Immune Response Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Antigen Processing And Presentation Positive Regulation Of Mitophagy Maintenance Of Gastrointestinal Epithelium Response To Muramyl Dipeptide Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Appetite P38MAPK Cascade Macromolecule Metabolic Process Positive Regulation Of Interleukin-17 Production Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Polyubiquitination	Protein Methylation Negative Regulation Of NF-kappaB Transcription Factor Activity Peptidyl-lysine Methylation NF-kappaB Binding Protein-lysine N-methyltransferase Activity S-adenosyl-L-methionine Binding Peptidyl-lysine Monomethylation Negative Regulation Of DNA-binding Transcription Factor Activity Stem Cell Differentiation Macromolecule Methylation Maintenance Of Cell Number Stem Cell Population Maintenance Methyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Methylation
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