ZNF668 and DCTPP1

		ZNF668	DCTPP1
Description		zinc finger protein 668	dCTP pyrophosphatase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding Pyrophosphatase Activity Hydrolase Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity DCTP Diphosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of Transcription By RNA Polymerase II	DCTP Catabolic Process Nucleoside Triphosphate Catabolic Process DNA Protection DTTP Catabolic Process
Pathways		Generic Transcription Pathway	Interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Response to metformin (IC50) ( 28173075)	Urinary sodium excretion ( 31409800)
Interacting Genes		8 interacting genes: BYSL HMGB2 PRPF31 VCX VHL ZNF165 ZNF250 ZNF792	12 interacting genes: APP FMR1 FXR1 FXR2 LNX1 NIF3L1 NOA1 NTAQ1 PSMA1 SDCBP SPG21 USP7
Entrez ID		79759	79077
HPRD ID		07828	18310
Ensembl ID		ENSG00000167394	ENSG00000179958
Uniprot IDs		A8K1I4 Q96K58	Q9H773
PDB IDs			7MU5
Enriched GO Terms of Interacting Partners?		Nucleus Ribonucleoprotein Complex Localization DTTP Catabolic Process DCTP Diphosphatase Activity DCTP Catabolic Process Non-sequence-specific DNA Binding, Bending U4atac SnRNP Pyrimidine Deoxyribonucleotide Binding SnRNP Binding U4atac SnRNA Binding	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Translation Regulator Activity Growth Cone Filopodium Postsynapse RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Protein Heterodimerization Activity Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of Synaptic Plasticity Regulation Of Receptor Internalization Cytoplasmic Ribonucleoprotein Granule Presynapse Collateral Sprouting Cytoplasmic Stress Granule DNA Repair Positive Regulation Of Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization MRNA Transport MRNA 3'-UTR Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Dentate Gyrus Development Neuron Maturation Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Frizzled Binding Dendritic Spine RNA Transport Positive Regulation Of Translation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Intracellular Transport Of Viral Material Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Adrenal Cortex Development Regulation Of Long-term Synaptic Potentiation Chromosome Regulation Of RNA Metabolic Process Regulation Of Translation Molecular Condensate Scaffold Activity
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