NARS2 and TMEM126B

		NARS2	TMEM126B
Description		asparaginyl-tRNA synthetase 2, mitochondrial	transmembrane protein 126B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Aminoacyl-tRNA Ligase Activity Asparagine-tRNA Ligase Activity ATP Binding Ligase Activity	Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Asparaginyl-tRNA Aminoacylation	Mitochondrion Organization Response To Food Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Mitochondrial tRNA aminoacylation	Complex I biogenesis
Drugs		Asparagine
Diseases
GWAS		Alzheimer's disease (survival time) ( 25649651) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Estimated glomerular filtration rate ( 31451708) High light scatter reticulocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990) Verbal declarative memory ( 25648963)	Height ( 19570815) Metabolite levels ( 23823483)
Interacting Genes			3 interacting genes: APP MRFAP1L1 UBC
Entrez ID		79731	55863
HPRD ID		08026	13715
Ensembl ID		ENSG00000137513	ENSG00000171204
Uniprot IDs		A0A8Q3SHL5 A0A8Q3SHT7 A0A8Q3WKF4 B3KPX5 H0YE96 Q96I59 Q9H5H1	Q8IUX1
PDB IDs
Enriched GO Terms of Interacting Partners?		Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cardiac Cell Fate Specification Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity Asparagine-tRNA Ligase Activity Asparaginyl-tRNA Aminoacylation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Central Nervous System Myelin Formation Axon Choice Point Recognition Positive Regulation Of Gastrulation Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion
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