STK33 and FPGT

		STK33	FPGT
Description		serine/threonine kinase 33	fucose-1-phosphate guanylyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Manchette Nucleus Cytoplasm Cytoskeleton Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding GTP Binding Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Nucleotidyltransferase Activity Fucose-1-phosphate Guanylyltransferase Activity
	Biological Process	Spermatogenesis Cell Differentiation Mitotic DNA Damage Checkpoint Signaling Protein Autophosphorylation Manchette Assembly	Fucose Metabolic Process GDP-L-fucose Biosynthetic Process
Pathways			GDP-fucose biosynthesis
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 19079261 26426971 28448500 28892062) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Intake of total sugars ( 31005972) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Small cell lung carcinoma ( 28604730)	Age at first sexual intercourse ( 34211149) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Menarche (age at onset) ( 27182965) Mental health study participation (completed survey) ( 31263887) Parental longevity (combined parental age at death) ( 29227965)
Interacting Genes		5 interacting genes: APP GLYCTK HPD USP15 USP5
Entrez ID		65975	8790
HPRD ID		09642	06790
Ensembl ID		ENSG00000130413	ENSG00000254685
Uniprot IDs		B3KS39 B4DDH2 F8WAK5 Q9BYT3	A0A0S2Z4P4 A0A0S2Z5C6 O14772
PDB IDs		8VF6
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Lysosome Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling 4-hydroxyphenylpyruvate Dioxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Deubiquitinase Activity Regulation Protein Catabolic Process At Presynapse Cysteine-type Endopeptidase Activity GDP-L-fucose Biosynthetic Process Fucose-1-phosphate Guanylyltransferase Activity Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Fructose Catabolic Process Fructose Catabolic Process To Hydroxyacetone Phosphate And Glyceraldehyde-3-phosphate Glycerate Kinase Activity Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway L-tyrosine Catabolic Process	Prostaglandin F Receptor Activity Cellular Response To Prostaglandin D Stimulus Manchette Assembly Parturition Manchette
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