SLC39A8 and STPG2

		SLC39A8	STPG2
Description		solute carrier family 39 member 8	sperm tail PG-rich repeat containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Organelle Membrane
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Symporter Activity Metal Ion Transmembrane Transporter Activity Monoatomic Cation:bicarbonate Symporter Activity Zinc:bicarbonate Symporter Activity
	Biological Process	DNA-templated Transcription Regulation Of DNA-templated Transcription Protein N-linked Glycosylation Arginine Metabolic Process Monoatomic Ion Transport Cobalt Ion Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Mercury Ion Transport Bicarbonate Transport Metal Ion Transport Intracellular Monoatomic Cation Homeostasis Intracellular Manganese Ion Homeostasis Extracellular Matrix Organization Regulation Of Membrane Potential Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Inflammatory Response Transmembrane Transport Leukocyte Adhesion To Arterial Endothelial Cell Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Zinc Ion Transmembrane Transport Zinc Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Iron Ion Import Across Plasma Membrane Cellular Detoxification Of Cadmium Ion Cartilage Homeostasis Mitochondrial Manganese Ion Transmembrane Transport
Pathways		Zinc influx into cells by the SLC39 gene family
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30336701 30940813 33861876) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Alcohol use disorder (total score) ( 30336701) Allergic disease (asthma, hay fever or eczema) ( 29679657) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anterior thalamic nuclei volume ( 34006833) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Blood pressure ( 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 20935630 25673413 26961502 28448500 28552196 29273807 29381148) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 26604143 33045005) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Copper levels ( 26025379) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diastolic blood pressure ( 21909115 27618452 27841878 28739976 30578418) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Eosinophil percentage of white cells ( 32888494) Erythrocyte cadmium concentration in never smokers ( 27005419) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) Hand grip strength ( 29691431) HDL cholesterol ( 20686565 24097068 25961943 30275531) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) Hypertension ( 21909115 31879980) Inflammatory bowel disease ( 28067908) Initial pursuit acceleration ( 29064472) Intelligence (MTAG) ( 29326435) Lateral thalamic nuclei volume ( 34006833) LDL cholesterol levels ( 32203549) Left-handedness ( 32989287) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Manganese levels ( 26025379) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Multisite chronic pain ( 31194737 33830993) NT-proBNP levels in acute coronary syndrome ( 26908625) Obese vs. thin ( 30677029) Parkinson's disease ( 32201043) Platelet distribution width ( 27863252 32888494) Problematic alcohol use ( 32451486) Red blood cell count ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656) Serum total protein levels ( 29403010) Shoulder impingement or rotator cuff tear ( 33482370) Sleep duration (short sleep) ( 30846698) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 21909115 27618447 27618452 27841878 28739976 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731 32203549) Voxel-wise structural brain imaging measurements ( 30649180) vWF levels ( 30586737) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006) Youthful appearance (self-reported) ( 32339537)	Adventurousness ( 30643258) Bitter non-alcoholic beverage consumption ( 31046077) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297) Waist-to-hip ratio adjusted for body mass index ( 27195708)
Interacting Genes		1 interacting genes: PTGER4
Entrez ID		64116	285555
HPRD ID		12286	14650
Ensembl ID		ENSG00000138821	ENSG00000163116
Uniprot IDs		Q9C0K1	Q8N412
PDB IDs
Enriched GO Terms of Interacting Partners?		Bone Development Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Chondrocyte Proliferation Transforming Growth Factor Beta Receptor Activity, Type I Ovarian Cumulus Expansion Prostaglandin E Receptor Activity Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Prostaglandin Receptor Activity Nucleosome Array Spacer Activity Zygotic Specification Of Dorsal/ventral Axis	Leukocyte Adhesion To Arterial Endothelial Cell Mitochondrial Manganese Ion Transmembrane Transport Zinc:bicarbonate Symporter Activity Iron Ion Import Across Plasma Membrane Plasma Membrane Selenite Transport Mercury Ion Transport Cellular Detoxification Of Cadmium Ion Intracellular Manganese Ion Homeostasis Cadmium Ion Transmembrane Transport Detoxification Of Cadmium Ion Iron Import Into Cell Monoatomic Cation:bicarbonate Symporter Activity Manganese Ion Homeostasis Cartilage Homeostasis Zinc Ion Import Across Plasma Membrane Cobalt Ion Transport Manganese Ion Transmembrane Transport Manganese Ion Transport Iron Ion Transmembrane Transport Arginine Metabolic Process Metal Ion Transmembrane Transporter Activity Leukocyte Adhesion To Vascular Endothelial Cell Zinc Ion Transmembrane Transporter Activity Bicarbonate Transport Zinc Ion Transmembrane Transport Zinc Ion Transport Intracellular Zinc Ion Homeostasis Iron Ion Transport Organelle Membrane Leukocyte Cell-cell Adhesion Intracellular Iron Ion Homeostasis Protein N-linked Glycosylation Inorganic Cation Import Across Plasma Membrane Symporter Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Cellular Detoxification Import Across Plasma Membrane Anatomical Structure Homeostasis Tissue Homeostasis Negative Regulation Of Inflammatory Response Alpha-amino Acid Metabolic Process Glycoprotein Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization Basolateral Plasma Membrane Glycoprotein Metabolic Process Amino Acid Metabolic Process Negative Regulation Of Defense Response Regulation Of Canonical NF-kappaB Signal Transduction
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