SLC12A5 and TTPAL

		SLC12A5	TTPAL
Description		solute carrier family 12 member 5	alpha tocopherol transfer protein like
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Dendrite Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Cell Periphery Glutamatergic Synapse Postsynaptic Specialization Membrane	Membrane Trans-Golgi Network Membrane
	Molecular Function	Ammonium Channel Activity Chloride Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Metal Ion Binding	Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Chloride Transport Cell Volume Homeostasis Hypotonic Response Chemical Synaptic Transmission Learning Response To Xenobiotic Stimulus Intracellular Chloride Ion Homeostasis Developmental Process Multicellular Organism Growth Thermosensory Behavior Intracellular PH Reduction Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Dendritic Spine Development Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Postsynaptic Neurotransmitter Receptor Diffusion Trapping Regulation Of Postsynapse Assembly Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Cation-coupled Chloride cotransporters
Drugs		Potassium chloride Bumetanide
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Response to antidepressants (symptom improvement) ( 33589590) Reticulocyte count ( 32888494) Systemic sclerosis ( 29293537) Triglyceride levels ( 32154731)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: CCR4 F2RL1	1 interacting genes: TGFBR1
Entrez ID		57468	79183
HPRD ID		09469	09837
Ensembl ID		ENSG00000124140	ENSG00000124120
Uniprot IDs		Q9H2X9	B2RA57 Q9BTX7
PDB IDs		6M23 7D8Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytosolic Calcium Ion Concentration Phosphatidylinositol-3,5-bisphosphate Binding Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Histone H1 Reader Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Chromatin Lock Complex SAM Domain Binding UDP-glucose Transmembrane Transport Calcium-mediated Signaling Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Mature Conventional Dendritic Cell Differentiation Regulation Of Neutrophil Mediated Cytotoxicity Negative Regulation Of Macromolecule Metabolic Process Regulation Of System Process Positive Regulation Of Killing Of Cells Of Another Organism Thrombin-activated Receptor Activity Regulation Of Muscle Contraction Z Disc Histone H4K20me2 Reader Activity Protein O-linked Glycosylation Via Fucose Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Junctional Membrane Complex Regulation Of Cardiac Muscle Tissue Development	Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Type II Transforming Growth Factor Beta Receptor Binding Ventricular Compact Myocardium Morphogenesis Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Extracellular Matrix Assembly Vascular Endothelial Cell Proliferation Transforming Growth Factor Beta Receptor Activity Epicardium Morphogenesis Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endothelial Cell Activation Transforming Growth Factor Beta Receptor Activity, Type I Transforming Growth Factor Beta Ligand-receptor Complex Thermosensory Behavior Postsynaptic Neurotransmitter Receptor Diffusion Trapping Ammonium Transmembrane Transport Ammonium Channel Activity Potassium:chloride Symporter Activity Chloride:monoatomic Cation Symporter Activity Receptor Diffusion Trapping Intracellular Chloride Ion Homeostasis Coronary Vasculature Morphogenesis Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Hypotonic Response Ventricular Trabecula Myocardium Morphogenesis Dendritic Spine Development I-SMAD Binding Pharyngeal System Development Chloride Ion Homeostasis Chloride Transmembrane Transporter Activity Heart Trabecula Morphogenesis Transforming Growth Factor Beta Binding Serine/threonine Protein Kinase Complex Monoatomic Anion Homeostasis Regulation Of Extracellular Matrix Assembly Filopodium Assembly Negative Regulation Of Chondrocyte Differentiation Response To Cholesterol Embryonic Cranial Skeleton Morphogenesis
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