ISY1 and ACAD9

		ISY1	ACAD9
Description		ISY1 spliceosome associated protein	acyl-CoA dehydrogenase family member 9
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Post-mRNA Release Spliceosomal Complex Post-spliceosomal Complex	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane
	Molecular Function	RNA Binding Protein Binding	Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity
	Biological Process	Generation Of Catalytic Spliceosome For Second Transesterification Step MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Mitochondrial Respiratory Chain Complex I Assembly Medium-chain Fatty Acid Metabolic Process
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	Complex I biogenesis
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Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Dental caries ( 23064961) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		9 interacting genes: CCNC EXOC8 FAM90A1 KDM8 LMO1 LMO2 MLH1 PTBP2 WBP4
Entrez ID		57461	28976
HPRD ID		13834	12412
Ensembl ID		ENSG00000240682	ENSG00000177646
Uniprot IDs		Q9ULR0	Q9H845 Q9H9W4
PDB IDs		5YZG 6FF7 6ZYM 7A5P 8C6J 8CH6 8I0W 8RO2 9FMD	8PHE 8PHF
Enriched GO Terms of Interacting Partners?			Endoplasmic Reticulum Organization Pronephric Nephron Development Protein-DNA Covalent Cross-linking Activity Post-spliceosomal Complex Regulation Of DNA Recombination DNA-(abasic Site) Binding Generation Of Catalytic Spliceosome For Second Transesterification Step Endosome Fission Endosome Membrane Tubulation Endoplasmic Reticulum-endosome Membrane Contact Site Signal Sequence Binding Membrane Tubulation Sec61 Translocon Complex MRNA 3'-splice Site Recognition SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Protein-DNA Covalent Cross-linking Repair Post-mRNA Release Spliceosomal Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining SRP-dependent Cotranslational Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nephron Development Somatic Hypermutation Of Immunoglobulin Genes DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Somatic Diversification Of Immune Receptors Via Somatic Mutation Prp19 Complex U2-type Catalytic Step 1 Spliceosome Cotranslational Protein Targeting To Membrane
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