TMPRSS15 and RPS4Y1

		TMPRSS15	RPS4Y1
Description		transmembrane serine protease 15	ribosomal protein S4 Y-linked 1
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GO Annotations	Cellular Component	Brush Border Membrane	Nucleus Nucleoplasm Cytosol Ribosome Membrane Cytosolic Small Ribosomal Subunit Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	RNA Binding Structural Constituent Of Ribosome RRNA Binding
	Biological Process	Proteolysis	Translation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases		Enterokinase deficiency
GWAS		Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)
Interacting Genes		1 interacting genes: SPINK1	3 interacting genes: CALM1 CLK1 MEOX2
Entrez ID		5651	6192
HPRD ID		05972	15963
Ensembl ID		ENSG00000154646	ENSG00000129824
Uniprot IDs		P98073	P22090
PDB IDs		4DGJ 6ZOV 7WQX	5AJ0 5FLX 6OLG 6OLZ
Enriched GO Terms of Interacting Partners?		Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Adenine Biosynthetic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Adenine Metabolic Process	Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Somite Specification Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Titin Binding Detection Of Calcium Ion Calcium Channel Inhibitor Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Segment Specification Somite Development Protein Phosphatase Activator Activity Calyx Of Held Negative Regulation Of Transporter Activity Cellular Response To Interferon-beta Catalytic Complex Presynaptic Cytosol Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Cell Action Potential Calcineurin-mediated Signaling Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Myelin Sheath
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