WDR45B and CCDC40

		WDR45B	CCDC40
Description		WD repeat domain 45B	coiled-coil domain 40 molecular ruler complex subunit
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GO Annotations	Cellular Component	Phagophore Assembly Site Lysosome Cytosol Phagophore Assembly Site Membrane	Extracellular Region Cytoplasm Cilium Axoneme Motile Cilium Cell Projection
	Molecular Function	Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3-phosphate Binding TSC1-TSC2 Complex Binding Phosphatidylinositol-3,5-bisphosphate Binding	Molecular_function Protein Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Autophagy Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Nucleophagy Glycophagy	Heart Looping Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Regulation Of Cilium Beat Frequency Determination Of Left/right Symmetry Flagellated Sperm Motility Lung Development Axoneme Assembly Determination Of Pancreatic Left/right Asymmetry Inner Dynein Arm Assembly Motile Cilium Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Protein Localization To Cilium Axonemal Dynein Complex Assembly Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry
Pathways		Macroautophagy
Drugs
Diseases			Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS
Interacting Genes		1 interacting genes: APP	1 interacting genes: APP
Entrez ID		56270	55036
HPRD ID		15669	10976
Ensembl ID		ENSG00000141580	ENSG00000141519
Uniprot IDs		Q5MNZ6	Q4G0X9
PDB IDs		6IYY 6KLR 8ZQG 9C9I 9CE3	8J07
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Mitotic Cell Cycle Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Small Molecule Metabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Microtubule-based Transport Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Pentose-phosphate Shunt Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Determination Of Pancreatic Left/right Asymmetry Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Phosphate Metabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Determination Of Liver Left/right Asymmetry TORC1 Complex Regulation Of Pentose-phosphate Shunt Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cell Cycle Axon Choice Point Recognition	Positive Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Lysosome Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Autophagosome Organization Autophagosome Assembly Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Vacuole Organization Cellular Response To Starvation TSC1-TSC2 Complex Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Protein-macromolecule Adaptor Activity Positive Regulation Of Pentose-phosphate Shunt Response To Starvation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Lamin Filament Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway
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