CFC1 and ELF4

Data Source: HiPPIP (Novel)

		CFC1	ELF4
Name		cryptic, EGF-CFC family member 1	E74 like ETS transcription factor 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Membrane Side Of Membrane	Chromatin Nucleus Nucleoplasm Nuclear Body PML Body
	Molecular Function	Nodal Binding Activin Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Blood Vessel Development Signal Transduction Determination Of Left/right Symmetry Gastrulation Heart Development Anterior/posterior Pattern Specification Nodal Signaling Pathway	Natural Killer Cell Proliferation NK T Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response
Pathways		Signaling by NODAL Regulation of signaling by NODAL	None
Diseases		Conotruncal heart malformations, including: Double-outlet right ventricle; Persistent truncus arteriosus; Conotruncal anomaly face syndrome Heterotaxy; Situs ambiguus	None
GWAS		No GWAS studies recorded	Bipolar disorder ( 31043756 )
Novel Interactors		9 novel interactors: CCDC74B ELF4 MSN MZT2B NDUFS1 PFDN6 PLEKHB2 SMPD4 TSN	2 novel interactors: CFC1 PSMD8
Interacting Genes		None recorded	10 interacting genes: CASP4 FBXO4 FBXO7 NFE2L2 NPM1 PML RUNX1 SET SKP2 UBB
Entrez ID		55997	2000
HPRD ID		05548	06499
Ensembl ID		ENSG00000136698	ENSG00000102034
Uniprot IDs		A0A087WWV2 A0A087WX98 P0CG37	Q99607
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Programmed Cell Death Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Post-translational Protein Modification Cellular Senescence SCF Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Regulation Of Cellular Response To Stress Regulation Of Neuron Apoptotic Process Regulation Of Protein Metabolic Process Protein Ubiquitination Ubiquitin Protein Ligase Binding Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Protein Polyubiquitination Regulation Of Signal Transduction By P53 Class Mediator Protein-containing Complex Regulation Of Proteolysis Catabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Stability Macromolecule Metabolic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Regulation Of Protein Polyubiquitination Nucleoplasm Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway Cytosol Protein Modification Process Protein-DNA Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Response To Endoplasmic Reticulum Stress