IFT122 and SLCO2A1

		IFT122	SLCO2A1
Description		intraflagellar transport 122	solute carrier organic anion transporter family member 2A1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cilium Membrane Intraciliary Transport Particle A Nuclear Membrane Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Ciliary Tip Non-motile Cilium	Cytoplasm Lysosome Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding	Lipid Transporter Activity Prostaglandin Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Neural Tube Closure Embryonic Body Morphogenesis Spinal Cord Dorsal/ventral Patterning Cell Projection Organization Embryonic Heart Tube Development Embryonic Forelimb Morphogenesis Intracellular Signal Transduction Intraciliary Anterograde Transport Intraciliary Retrograde Transport Intraciliary Transport Negative Regulation Of Smoothened Signaling Pathway Camera-type Eye Morphogenesis Limb Development Cilium Assembly Embryonic Heart Tube Left/right Pattern Formation Protein Localization To Cilium Establishment Of Protein Localization To Organelle Non-motile Cilium Assembly	Lipid Transport Prostaglandin Transport Sodium-independent Organic Anion Transport Transmembrane Transport
Pathways		Hedgehog 'off' state Intraflagellar transport	Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) Organic anion transport by SLCO transporters
Drugs
Diseases		Cranioectodermal dysplasia
GWAS		A body shape index ( 34021172) Diisocyanate-induced asthma ( 25918132) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Colorectal cancer ( 30529582) Height ( 31562340)
Interacting Genes		2 interacting genes: DSCAM DSCR9
Entrez ID		55764	6578
HPRD ID		06922	03269
Ensembl ID		ENSG00000163913	ENSG00000174640
Uniprot IDs		A0A8I5KSG5 A0A8I5KT04 A0A8I5KTL4 A0A8I5KUU2 A0A8I5KVC7 A0A8I5KWK4 A0A8I5KXT5 A0A8I5QKR8 A0A8I5QKX8 A0A8J9A3C6 B3KUD1 B4DST2 Q9HBG6	Q92959
PDB IDs		8BBE 8BBF 8BBG 8FGW 8FH3	3MRR 8KGI 8KGV 8KGW
Enriched GO Terms of Interacting Partners?		Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding	Intraciliary Transport Particle A Embryonic Heart Tube Left/right Pattern Formation Body Morphogenesis Spinal Cord Dorsal/ventral Patterning Embryonic Body Morphogenesis Intraciliary Retrograde Transport Left/right Pattern Formation Intraciliary Anterograde Transport Embryonic Heart Tube Development Camera-type Eye Morphogenesis Embryonic Forelimb Morphogenesis Non-motile Cilium Non-motile Cilium Assembly Ciliary Tip Photoreceptor Connecting Cilium Forelimb Morphogenesis Intraciliary Transport Negative Regulation Of Smoothened Signaling Pathway Limb Development Eye Morphogenesis Protein Localization To Cilium Dorsal/ventral Pattern Formation Sensory Organ Morphogenesis Tube Closure Embryonic Limb Morphogenesis Regulation Of Smoothened Signaling Pathway Neural Tube Closure Limb Morphogenesis Tube Formation Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Tube Development Microtubule-based Transport Epithelium Development Cilium Assembly Nuclear Membrane Regionalization Cilium Organization Ciliary Basal Body Establishment Of Protein Localization To Organelle Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Microtubule-based Movement Pattern Specification Process
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