TMEM127 and LMAN2L

		TMEM127	LMAN2L
Description		transmembrane protein 127	lectin, mannose binding 2 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle
	Molecular Function	Small GTPase Binding	Protein Binding D-mannose Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Endosome Organization Negative Regulation Of Cell Population Proliferation Regulation Of TOR Signaling Negative Regulation Of TOR Signaling	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport
Pathways			COPII-mediated vesicle transport Cargo concentration in the ER
Drugs
Diseases
GWAS		Type 2 diabetes (adjusted for BMI) ( 30297969)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 20351715 21926972 22182935 28072414 31043756 34002096) Blood protein levels ( 30072576)
Interacting Genes			2 interacting genes: MAL ZDHHC17
Entrez ID		55654	81562
HPRD ID		07917	17286
Ensembl ID		ENSG00000135956	ENSG00000114988
Uniprot IDs		C9J4H2 O75204	B4DI83 B4DVH1 B4E308 Q9H0V9
PDB IDs
Enriched GO Terms of Interacting Partners?		D-mannose Binding COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment	Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Response To Water Deprivation Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Cellular Response To Water Deprivation Cytoplasmic Vesicle Membrane Protein Localization To Paranode Region Of Axon Membrane Raft Polarization Peptidase Activator Activity Involved In Apoptotic Process Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Ubiquitin-dependent Endocytosis Response To Water Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Metanephric Collecting Duct Development Response To Mercury Ion Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Regulation Of Neurotrophin TRK Receptor Signaling Pathway Mucociliary Clearance Molecular Carrier Activity Type 2 Immune Response Collecting Duct Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Lipid Transfer Activity Vacuolar Proton-transporting V-type ATPase, V1 Domain Water Channel Activity Golgi-associated Vesicle Membrane Vacuolar Proton-transporting V-type ATPase Complex Apical Protein Localization Ubiquinone Biosynthetic Process
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