RSAD1 and UTP18

		RSAD1	UTP18
Description		radical S-adenosyl methionine domain containing 1	UTP18 small subunit processome component
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Nucleus Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome
	Molecular Function	Catalytic Activity Coproporphyrinogen Oxidase Activity Heme Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	RNA Binding Protein Binding
	Biological Process	Porphyrin-containing Compound Biosynthetic Process	RRNA Processing Ribosomal Small Subunit Biogenesis
Pathways			rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Hip circumference adjusted for BMI ( 34021172) Menarche (age at onset) ( 27182965) Metabolite levels ( 23823483)
Interacting Genes			3 interacting genes: CSNK2A1 ERBB2 OGT
Entrez ID		55316	51096
HPRD ID		07737	10825
Ensembl ID		ENSG00000136444	ENSG00000011260
Uniprot IDs		Q9HA92	Q9Y5J1
PDB IDs			7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Pwp2p-containing Subcomplex Of 90S Preribosome Small-subunit Processome Ribosomal Small Subunit Biogenesis Nuclear Membrane RRNA Processing Ribonucleoprotein Complex Biogenesis RRNA Metabolic Process	Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Sebum Secreting Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Response To Stress Adaptive Immune Response Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Sin3-type Complex Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cellular Response To Mechanical Stimulus Positive Regulation Of Type II Interferon Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Differentiation Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Extrathymic T Cell Differentiation Protein Localization To Vacuole Positive Regulation Of Signal Transduction ERBB3:ERBB2 Complex Relaxation Of Skeletal Muscle Coproporphyrinogen Oxidase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Translation Transferase Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body RNA Polymerase I Core Binding Protein O-acetylglucosaminyltransferase Activity Toll-like Receptor 8 Signaling Pathway Identical Protein Binding
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